CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID705
Family Name Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-methylbenzoyl)-4-benzylpiperidine Family
No. of Seeds 8 No. of Other Members 37
Family Centroid CFAMM00217307 Functional Category Investigative Drug with Natural Product
Superfamily Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-methylbenzoyl)-4-benzylpiperidine Superfamily
Class Class 1315

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Opioid receptor Ligand Methadone Family 3 39
Histamine H1 receptor Ligand Azelastine Family 14 29
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Aldose reductase Inhibitor Alrestatin Family 2 11
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-4-isobutyl-ben... 4 43
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor Bexlosteride... 5 23
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Acetyl-CoA carboxylase 1 and Acetyl-CoA carboxylase 2 Inhibito... 1 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Histone deacetylase 1 Inhibitor N-hydroxy-6-oxo-6-phenylhexana... 7 7
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2-nap... 3 3
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2,3,3... 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
C-C chemokine receptor type 5 ligand AC1NUIO8 family 12 11
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-3-methyl-... 3 4
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 13
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 2
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 18
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Acetylcholinesterase inhibitor AC1MIM21 family 2 7
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 4
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Metabotropic glutamate receptor 5 ligand SureCN504295 family 1 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[[... 2 10
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 7 3
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Renin and Potassium voltage-gated channel subfamily H member 2... 3 2
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 7 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Nociceptin receptor and Kappa-type opioid receptor ligand Pipe... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... 4 0
5-hydroxytryptamine receptor 1A and Alpha-2B adrenergic recept... 2 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 1
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Tryptase alpha/beta-1 and Trypsin-1 inhibitor AGN-PC-074JFM fa... 3 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Plasmepsin-2 inhibitor SureCN8292428 family 1 2
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-bromobenz... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Histamine H3 receptor ligand [(3aR,6aR)-4-[4-[2-[(2R)-2-methyl... 6 0
Oxytocin receptor and Vasopressin V1a receptor ligand N-(cyclo... 4 5
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Lanosterol synthase and Cycloartenol synthase inhibitor (4-bro... 1 2
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 22
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2R)-8-acetyl-5-... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TEL... 1 7
Aldose reductase inhibitor SureCN8804611 family 2 0
Substance-P receptor ligand 1-benzyl-3-[bis(4-chlorophenyl)met... 1 3
Substance-P receptor ligand AGN-PC-0760FI family 1 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1
Muscarinic acetylcholine receptor M2 ligand 3-[(1Z)-1-benzylid... 2 0
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
Lanosterol synthase and Squalene--hopene cyclase inhibitor AGN... 2 5
Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)... 3 0
Reverse transcriptase/RNaseH inhibitor (R)-(+)9B-(3-METHYL)PHE... 5 24
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 1 1
Mitogen-activated protein kinase 8 inhibitor methyl 2-benzyl-1... 1 2
Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... 1 0
Voltage-dependent T-type calcium channel subunit alpha-1I and ... 1 0
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Thioredoxin reductase 1, cytoplasmic inhibitor 5-fluoro-2-[2-(... 3 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 3 0
Voltage-dependent T-type calcium channel subunit alpha-1H and ... 2 0
Putative Bioactive [3-[benzoyl(hydroxy)amino]-1-(3,4-dichlorop... 2 0
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
Histone deacetylase 6 inhibitor AGN-PC-0C5HOH family 1 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00217297 CHEMBL126255 Bioactive SureCN4917854
CFAMM00217284 CHEMBL127802 Bioactive SureCN4929262
CFAMM00217290 DNC007809 Investigative Drug (4-benzylpiperidin-1-yl)(2-fluorophenyl)methanone
CFAMM00217321 DNC007807 Investigative Drug (4-benzylpiperidin-1-yl)(m-tolyl)methanone
CFAMM00217272 DNC007810 Investigative Drug (4-benzylpiperidin-1-yl)(3-chlorophenyl)methanone
CFAMM00217307 DNC002621 Investigative Drug N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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