| Cousin Family Names | Seeds | Members |
|---|
| Mu-type opioid receptor Ligand Fentanyl Family | 9 | 647 |
| Opioid receptor Ligand Methadone Family | 3 | 39 |
| Histamine H1 receptor Ligand Azelastine Family | 14 | 29 |
| 5-hydroxytryptamine receptor 3A Ligand Palonosetron Family | 12 | 403 |
| Alpha adrenergic receptor Ligand Droperidol Family | 20 | 244 |
| Sodium channel protein type 5 subunit alpha Ligand Procainamid... | 7 | 291 |
| Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family | 14 | 443 |
| Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family | 5 | 255 |
| Glutathione S-transferase Inhibitor Praziquantel Family | 5 | 167 |
| Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... | 29 | 276 |
| Tumor necrosis factor Inhibitor Thalidomide Family | 3 | 50 |
| Acetylcholinesterase Inhibitor Ambenonium Family | 4 | 71 |
| DNA Binder Procarbazine Family | 8 | 358 |
| Noradrenergic re-uptake Inhibitor Milnacipran Family | 7 | 51 |
| Peripheral carotid chemoreceptor Ligand Doxapram Family | 4 | 36 |
| Microsomal triglyceride transfer protein large subunit Inhibit... | 15 | 208 |
| Neuromedin-K receptor Ligand Osanetant Family | 38 | 192 |
| Motilin receptor Ligand GSK962040 Family | 30 | 457 |
| Substance-P receptor Ligand Orvepitant Family | 11 | 46 |
| Substance-K receptor and Substance-P receptor Ligand DNK-333 F... | 15 | 95 |
| 5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... | 2 | 18 |
| Tumor necrosis factor Inhibitor Talactoferrin Alfa Family | 26 | 131 |
| K-604 family | 4 | 71 |
| Pan-DAC Inhibitor AR-42 Family | 21 | 153 |
| Bavisant family | 9 | 65 |
| 5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... | 22 | 207 |
| Aldose reductase Inhibitor Alrestatin Family | 2 | 11 |
| Sodium- and chloride-dependent glycine transporter 1 Inhibitor... | 11 | 67 |
| Potassium voltage-gated channel subfamily A member 5 Ligand S-... | 34 | 206 |
| Dipeptidyl peptidase 4 Inhibitor Denagliptin Family | 24 | 151 |
| Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-4-isobutyl-ben... | 4 | 43 |
| Hemagglutinin Inhibitor Cl 385319 Family | 18 | 101 |
| Neutrophil elastase Inhibitor FK-706 Family | 8 | 85 |
| Vasopressin V2 receptor Ligand FR161282 Family | 17 | 83 |
| Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... | 3 | 7 |
| Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... | 12 | 94 |
| Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... | 18 | 168 |
| Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... | 12 | 44 |
| Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... | 7 | 62 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... | 3 | 2 |
| 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... | 40 | 87 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor Bexlosteride... | 5 | 23 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... | 6 | 17 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... | 10 | 52 |
| Farnesyltransferase beta subunit, putative and Protein farnesy... | 6 | 3 |
| Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... | 7 | 13 |
| Neuromedin-K receptor Ligand PD-157672 Family | 9 | 37 |
| Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... | 1 | 12 |
| Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... | 13 | 77 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 10 | 28 |
| Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family | 6 | 0 |
| Acetyl-CoA carboxylase 1 and Acetyl-CoA carboxylase 2 Inhibito... | 1 | 0 |
| Delta-type opioid receptor and Kappa-type opioid receptor Liga... | 41 | 24 |
| Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... | 10 | 22 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... | 5 | 27 |
| Thyroid hormone receptor alpha and Thyroid hormone receptor be... | 4 | 10 |
| Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... | 2 | 1 |
| Delta-type opioid receptor and Kappa-type opioid receptor Liga... | 3 | 21 |
| Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... | 2 | 23 |
| Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... | 2 | 7 |
| Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... | 4 | 21 |
| 5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family | 15 | 46 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... | 2 | 8 |
| Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... | 4 | 18 |
| Histone deacetylase 1 Inhibitor N-hydroxy-6-oxo-6-phenylhexana... | 7 | 7 |
| Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... | 20 | 55 |
| Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... | 6 | 19 |
| Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... | 2 | 2 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 19 | 28 |
| Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... | 44 | 28 |
| Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... | 2 | 10 |
| Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... | 5 | 23 |
| Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... | 9 | 66 |
| Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2-nap... | 3 | 3 |
| Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... | 3 | 9 |
| Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2,3,3... | 1 | 0 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 4 | 31 |
| Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... | 2 | 80 |
| Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... | 8 | 13 |
| Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... | 9 | 86 |
| 5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... | 4 | 6 |
| 5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... | 6 | 10 |
| Prolyl endopeptidase Inhibitor SUAM-1221 Family | 42 | 47 |
| Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... | 24 | 8 |
| Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... | 8 | 9 |
| Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... | 14 | 11 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... | 1 | 7 |
| Substance-P receptor ligand AGN-PC-00FJ8P family | 6 | 10 |
| D(4) dopamine receptor ligand AGN-PC-074VC9 family | 2 | 3 |
| C-C chemokine receptor type 5 ligand AC1NUIO8 family | 12 | 11 |
| Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... | 6 | 0 |
| Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... | 1 | 2 |
| Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... | 2 | 4 |
| Mu-type opioid receptor and Kappa-type opioid receptor ligand ... | 1 | 2 |
| 72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... | 1 | 0 |
| Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... | 2 | 7 |
| Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-3-methyl-... | 3 | 4 |
| C-C chemokine receptor type 5 ligand AC1L9USC family | 3 | 2 |
| Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... | 6 | 4 |
| Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... | 4 | 0 |
| Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... | 3 | 1 |
| Kappa-type opioid receptor and Mu-type opioid receptor ligand ... | 5 | 11 |
| Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 3 | 13 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 1 | 4 |
| Sodium-dependent dopamine transporter and Sodium-dependent ser... | 5 | 2 |
| Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... | 1 | 1 |
| Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... | 14 | 4 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... | 1 | 18 |
| P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... | 3 | 4 |
| Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... | 2 | 2 |
| Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... | 1 | 3 |
| Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... | 2 | 3 |
| Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family | 1 | 3 |
| Kappa-type opioid receptor and Mu-type opioid receptor ligand ... | 1 | 2 |
| Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... | 9 | 0 |
| Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... | 1 | 7 |
| Acetylcholinesterase inhibitor AC1MIM21 family | 2 | 7 |
| 5-hydroxytryptamine receptor 1A ligand U93385 family | 4 | 1 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... | 2 | 4 |
| Neuromedin-K receptor ligand SureCN2477089 family | 2 | 4 |
| Prothrombin inhibitor AGN-PC-09QJ23 family | 2 | 5 |
| Metabotropic glutamate receptor 5 ligand SureCN504295 family | 1 | 7 |
| Kappa-type opioid receptor and Mu-type opioid receptor ligand ... | 1 | 4 |
| Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... | 7 | 16 |
| Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... | 2 | 0 |
| C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... | 4 | 9 |
| Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... | 6 | 0 |
| Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[[... | 2 | 10 |
| Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... | 3 | 22 |
| Kappa-type opioid receptor and Mu-type opioid receptor ligand ... | 3 | 0 |
| Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... | 8 | 4 |
| Follicle-stimulating hormone receptor ligand AGN-PC-005HER family | 5 | 2 |
| Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... | 3 | 3 |
| Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... | 5 | 1 |
| Delta-type opioid receptor and Potassium voltage-gated channel... | 3 | 2 |
| Delta-type opioid receptor and Mu-type opioid receptor ligand ... | 1 | 0 |
| Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... | 7 | 3 |
| Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... | 8 | 9 |
| Renin and Potassium voltage-gated channel subfamily H member 2... | 3 | 2 |
| Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... | 4 | 2 |
| Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... | 3 | 10 |
| Histamine H3 receptor and Potassium voltage-gated channel subf... | 9 | 0 |
| Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... | 9 | 1 |
| Sodium-dependent serotonin transporter and Sodium-dependent do... | 6 | 3 |
| Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... | 8 | 4 |
| Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... | 1 | 1 |
| Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... | 1 | 2 |
| Substance-P receptor ligand AGN-PC-073QYE family | 6 | 11 |
| Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... | 3 | 4 |
| C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... | 22 | 27 |
| Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... | 3 | 0 |
| Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... | 1 | 0 |
| C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... | 2 | 4 |
| Sodium-dependent dopamine transporter and Sodium-dependent ser... | 7 | 2 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 2 | 1 |
| Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... | 1 | 0 |
| P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... | 3 | 1 |
| C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... | 6 | 3 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 1 | 4 |
| Histamine H3 receptor ligand AGN-PC-01WA6E family | 10 | 1 |
| Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... | 6 | 0 |
| Nociceptin receptor and Kappa-type opioid receptor ligand Pipe... | 1 | 0 |
| Mu-type opioid receptor and Kappa-type opioid receptor ligand ... | 1 | 4 |
| Kappa-type opioid receptor and Mu-type opioid receptor ligand ... | 3 | 1 |
| 5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... | 4 | 0 |
| 5-hydroxytryptamine receptor 1A and Alpha-2B adrenergic recept... | 2 | 2 |
| Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... | 3 | 1 |
| Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... | 7 | 0 |
| Sodium-dependent dopamine transporter and Transporter inhibito... | 6 | 0 |
| Substance-P receptor and Potassium voltage-gated channel subfa... | 5 | 1 |
| C-C chemokine receptor type 5 and Potassium voltage-gated chan... | 4 | 0 |
| Tryptase alpha/beta-1 and Trypsin-1 inhibitor AGN-PC-074JFM fa... | 3 | 1 |
| Kappa-type opioid receptor ligand SureCN5629426 family | 3 | 2 |
| Mu-type opioid receptor and Delta-type opioid receptor ligand ... | 1 | 0 |
| 5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... | 1 | 0 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 5 | 5 |
| Plasmepsin-2 inhibitor SureCN8292428 family | 1 | 2 |
| Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... | 2 | 0 |
| P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-bromobenz... | 1 | 1 |
| Mu-type opioid receptor and Delta-type opioid receptor ligand ... | 1 | 0 |
| Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... | 4 | 9 |
| Histamine H3 receptor ligand [(3aR,6aR)-4-[4-[2-[(2R)-2-methyl... | 6 | 0 |
| Oxytocin receptor and Vasopressin V1a receptor ligand N-(cyclo... | 4 | 5 |
| C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... | 1 | 3 |
| Lanosterol synthase and Cycloartenol synthase inhibitor (4-bro... | 1 | 2 |
| Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... | 3 | 0 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 22 |
| Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family | 2 | 1 |
| C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... | 1 | 0 |
| 5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2R)-8-acetyl-5-... | 1 | 0 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 1 | 0 |
| Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... | 2 | 0 |
| Delta-type opioid receptor and Mu-type opioid receptor ligand ... | 3 | 3 |
| C-C chemokine receptor type 5 ligand AC1MHPA7 family | 2 | 2 |
| Delta-type opioid receptor and Mu-type opioid receptor ligand ... | 1 | 0 |
| Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TEL... | 1 | 7 |
| Aldose reductase inhibitor SureCN8804611 family | 2 | 0 |
| Substance-P receptor ligand 1-benzyl-3-[bis(4-chlorophenyl)met... | 1 | 3 |
| Substance-P receptor ligand AGN-PC-0760FI family | 1 | 0 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... | 1 | 3 |
| C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... | 1 | 1 |
| Muscarinic acetylcholine receptor M2 ligand 3-[(1Z)-1-benzylid... | 2 | 0 |
| Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... | 1 | 0 |
| Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... | 1 | 0 |
| Lanosterol synthase and Squalene--hopene cyclase inhibitor AGN... | 2 | 5 |
| Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)... | 3 | 0 |
| Reverse transcriptase/RNaseH inhibitor (R)-(+)9B-(3-METHYL)PHE... | 5 | 24 |
| 5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... | 1 | 1 |
| Mitogen-activated protein kinase 8 inhibitor methyl 2-benzyl-1... | 1 | 2 |
| Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... | 1 | 0 |
| Voltage-dependent T-type calcium channel subunit alpha-1I and ... | 1 | 0 |
| DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... | 1 | 0 |
| Thioredoxin reductase 1, cytoplasmic inhibitor 5-fluoro-2-[2-(... | 3 | 0 |
| Sodium- and chloride-dependent glycine transporter 1 inhibitor... | 3 | 0 |
| Voltage-dependent T-type calcium channel subunit alpha-1H and ... | 2 | 0 |
| Putative Bioactive [3-[benzoyl(hydroxy)amino]-1-(3,4-dichlorop... | 2 | 0 |
| Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... | 1 | 0 |
| Histone deacetylase 6 inhibitor AGN-PC-0C5HOH family | 1 | 1 |
| Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... | 3 | 1 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
|
