CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID727
Family Name Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-hydroxy Quinoline N-OXIDE Family
No. of Seeds 3 No. of Other Members 16
Family Centroid CFAMM00217643 Functional Category Investigative Drug with Natural Product
Superfamily Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-hydroxy Quinoline N-OXIDE Superfamily
Class Class 311

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
Dual specificity mitogen-activated protein kinase kinase Inhib... 5 13
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Glutamate receptor ionotropic, NMDA 1 Ligand Dcka, 5,7-dichlor... 2 7
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 4-methyl-5,6... 3 12
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Cruzipain Inhibitor 5-chloro-1-(4-chloro-benzyl)-1h-indole-2,3... 3 13
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Muscarinic acetylcholine receptor M5 Ligand VU0119498 Family 1 3
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-006C4... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-eth... 7 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Amyloid beta A4 protein inhibitor AGN-PC-08WTQK family 1 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 2 1
Histamine H3 receptor ligand SureCN3058680 family 4 0
Prelamin-A/C and Beta-lactamase inhibitor AE-562/12222510 family 1 9
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
Acetylcholinesterase inhibitor tmtfa family 1 2
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 1 2
Telomerase reverse transcriptase inhibitor AGN-PC-07ZBGW family 2 0
Arachidonate 5-lipoxygenase inhibitor (Z)-3-[benzyl(hydroxy)am... 4 0
Cytochrome P450 2C19 and 3-hydroxyacyl-CoA dehydrogenase type-... 1 5
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 1
(8-methyl-6-oxo-1,2,3a,4,5,6-hexahydro-3H-3,10b-diazaacephenan... 1 0
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3
1H-quinolin-4-one NP 4-(6-bromo-4-hydroxy-2-methylquinolin-3-y... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00217637 DNC007833 Investigative Drug 3-benzoyl-1-pentyl-1,4-dihydroquinolin-4-one
CFAMM00217654 DNC014839 Investigative Drug 1-hydroxy-2-dodecyl-4(1H)quinolone
CFAMM00217643 DNC002673 Investigative Drug 2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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