CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name FK506-binding protein 1A Inhibitor Gpi-1046 Family
No. of Seeds 4 No. of Other Members 10
Family Centroid CFAMM00218007 Functional Category Investigative Drug
Superfamily Cathepsin K and Cathepsin S Binder Superfamily
Class Class 1127

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
HIV-1 protease Inhibitor Atazanavir Family 16 58
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin K and Cathepsin S Inhibitor P2,p3 Ketoamide Derivati... 2 1
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
Cholecystokinin receptor type A ligand A-65186 family 2 6
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-(3-pyri... 1 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 4 8
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 2 3
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor (1-phenyl... 1 0
Probable G-protein coupled receptor 142 ligand (2S)-2-[[(2R)-o... 1 0
Thromboxane A2 receptor ligand SureCN8058805 family 2 1


External ID

Functional Category

Molecule Name

CFAMM00218016 CHEMBL149192 Bioactive SureCN7187
CFAMM00218005 CHEMBL423033 Bioactive AGN-PC-075R6M
CFAMM00218019 CHEMBL148517 Bioactive AGN-PC-075R6O
CFAMM00218007 DNC002704 Investigative Drug Gpi-1046

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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