CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID752
Family Name Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5-ol Family
No. of Seeds 5 No. of Other Members 82
Family Centroid CFAMM00218274 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Estrogen receptor beta and Oestrogen receptor Binder Superfamily
Class Class 1784

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Potassium voltage-gated channel subfamily H member 2 Ligand Am... 2 16
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Multidrug resistance-associated protein 1 Inhibitor Benzbromar... 2 16
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5... 1 9
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Fatty-acid amide hydrolase 1 Inhibitor Benzofuran-2-ylboronic ... 1 14
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 11
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1-benzofuran-5-yl)... 4 2
Thromboxane A2 receptor and Prostacyclin receptor ligand AGN-P... 2 30
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Estrogen receptor beta and Estrogen receptor ligand 4-[(7E)-7-... 1 1
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Cysteinyl leukotriene receptor 1 ligand 4-[(E)-1-carboxy-6-[4-... 2 9
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-075... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 13
Tyrosine-protein phosphatase non-receptor type 1 ligand (2S)-2... 9 3
Arachidonate 5-lipoxygenase inhibitor SureCN9740792 family 2 6
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Tyrosine-protein phosphatase non-receptor type 1 ligand 4-[4-[... 6 2
Glycogen synthase kinase-3 beta inhibitor 5-(5-methylfuran-2-y... 7 6
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07CO97 family 1 1
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dim... 3 2
Transient receptor potential M8 protein ligand 2-[1-diethoxyph... 1 0
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[3... 1 4
Tyrosine-protein phosphatase non-receptor type 1 ligand SureCN... 2 9
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand LY320135... 1 0
Prelamin-A/C and Inositol monophosphatase 1 inhibitor MLS00053... 1 1
Benzofurans Metabolite (R)-Bitalin A Family 1 9
Acenes Metabolite Musanolone D Family 2 1
Naphthofurans Metabolite Pyrocurzerenone Family 1 9
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
1,3-dimethylcyclohepta[c]furan-8-one NP 8-hydroxy-6-(4-methoxy... 10 0
5,6-dihydro-4H-furo[2',3':3,4]cyclohepta[1,2-b][1]benzofuran N... 3 0
NP 2,2,11,12-tetramethyl-3,4,8,9-tetrahydro-2h-cyclopenta[c]fu... 3 1
ethyl 4-[2-(hydroxyamino)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00218267 CHEMBL315475 Bioactive AGN-PC-074LJD
CFAMM00218199 DNC005054 Investigative Drug 2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol
CFAMM00218274 DNC002740 Investigative Drug 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL
CFAMM00218213 DNC008842 Investigative Drug 4'-((2-butylbenzofuran-3-yl)methyl)biphenyl-4-ol
CFAMM00218212 DNC008841 Investigative Drug 4'-(2-butylbenzofuran-3-yl)biphenyl-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26860 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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