CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID76
Family Name 5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family
No. of Seeds 35 No. of Other Members 20
Family Centroid CFAMM00178414 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor Ligand Quinagolide Superfamily
Class Class 62

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand N-0923 Family 6 41
D(3) dopamine receptor Ligand U-99194A Family 7 33
CORT-108297 family 46 44
Dapoxetine family 3 40
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
D(3) dopamine receptor ligand S 14297 family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
D(2) dopamine receptor and D(1A) dopamine receptor ligand (6aR... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Histamine H3 receptor ligand SureCN6071181 family 2 1
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
5-hydroxytryptamine receptor 1A ligand (Z)-1-diazonio-3-[[7-(d... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00178417 CHEMBL544757 Bioactive (7R,8S)-7-(dipropylamino)-8-methyl-5,6,7,8-tetrahydronaphthalen-1-ol;hydrochloride
CFAMM00178388 CHEMBL541621 Bioactive S(-)-8-OH-DPAT HBr
CFAMM00178396 CHEMBL24523 Bioactive (3aS,9bS)-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indol-9-ol
CFAMM00178410 CHEMBL567001 Bioactive (3aS,9bR)-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indol-9-ol
CFAMM00178403 CHEMBL9979 Bioactive (3aR)-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indol-9-ol
CFAMM00178416 CHEMBL25357 Bioactive (2S,3aR,9bS)-2-methyl-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indol-9-ol
CFAMM00178387 CHEMBL285351 Bioactive AGN-PC-073GQ1
CFAMM00178395 CHEMBL276185 Bioactive (3aS)-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indol-9-ol
CFAMM00178402 CHEMBL41436 Bioactive AG-H-22780
CFAMM00178386 CHEMBL1256754 Bioactive (+/-)-PPHT hydrochloride
CFAMM00178408 CHEMBL9980 Bioactive SureCN9080567
CFAMM00178385 CHEMBL542754 Bioactive AGN-PC-00OA7X
CFAMM00178407 CHEMBL1788118 Bioactive 7-[bis(3,3,3-tritritiopropyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
CFAMM00178406 CHEMBL543459 Bioactive (4aS,10bS)-4-propyl-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-10-ol;hydrochloride
CFAMM00178390 CHEMBL285774 Bioactive (2aR,8bR)-2-prop-2-enyl-2a,3,4,8b-tetrahydro-1H-naphtho[2,1-b]azet-8-ol
CFAMM00178405 CHEMBL164814 Bioactive (7R)-7-(diethylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
CFAMM00178414 DNC000018 Investigative Drug (S)-UH-301
CFAMM00178399 DNC003994 Investigative Drug UH-301
CFAMM00178383 DNC011816 Investigative Drug 2-Dipropylamino-1,2,3,4-tetrahydro-anthracen-9-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

43602 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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