CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID770
Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor PD-168393 Family
No. of Seeds 11 No. of Other Members 138
Family Centroid CFAMM00218587 Functional Category Investigative Drug with Natural Product
Superfamily Epidermal growth factor receptor and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 202

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Transient receptor potential cation channel subfamily V member... 1 0
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Transient receptor potential cation channel subfamily V member... 2 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor ligand (2R,3R)-3-[[4-(3-bromo... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Epidermal growth factor receptor ligand AGN-PC-076GWD family 2 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Epidermal growth factor receptor ligand AGN-PC-078X7L family 4 0
Epidermal growth factor receptor ligand (E)-N-[4-(3-bromoanili... 2 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Epidermal growth factor receptor ligand N-[4-(3-bromoanilino)-... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Epidermal growth factor receptor ligand 4-Anilinopyrido[3,4-d]... 2 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Epidermal growth factor receptor ligand AGN-PC-078X9P family 4 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Epidermal growth factor receptor ligand N-[4-(3-bromoanilino)q... 1 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
ATP-binding cassette sub-family G member 2 and cGMP-specific 3... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00218534 CHEMBL92086 Bioactive 4-anilinoquinazoline deriv. 17
CFAMM00218635 CHEMBL189779 Bioactive SureCN3241297
CFAMM00218649 CHEMBL53690 Bioactive SureCN2988814
CFAMM00218530 CHEMBL343722 Bioactive 6-Substituted 4-Anilinoquinazoline 15
CFAMM00218584 CHEMBL1221699 Bioactive N-(4-(Phenylamino)quinazolin-6-yl)acrylamide
CFAMM00218574 DNC002780 Investigative Drug N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE
CFAMM00218611 DNC014068 Investigative Drug PD-174265
CFAMM00218587 DNC004255 Investigative Drug PD-168393
CFAMM00218593 DNC006213 Investigative Drug CL-387785
CFAMM00218536 DNC004227 Investigative Drug N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide
CFAMM00218563 DNC004260 Investigative Drug N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543