CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID78
Family Name Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethylidene]-quinuclidine Hydrochloride 31 Family
No. of Seeds 12 No. of Other Members 92
Family Centroid CFAMM00179816 Functional Category Investigative Drug with Natural Product
Superfamily Histamine H1 receptor Ligand Doxepin Superfamily
Class Class 142

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Neuropeptide Y receptor type 5 Ligand NPY-5 Receptor Antagonis... 1 1
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 18 25
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 9
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
D(3) dopamine receptor ligand S 14297 family 1 2
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 12 0
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 4
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Histamine H3 receptor ligand 1-[4-(1'-cyclobutylspiro[3,4-dihy... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Muscarinic acetylcholine receptor M3 ligand AGN-PC-005QPZ family 1 0
Histamine H3 receptor ligand SureCN6071181 family 2 1
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN6716... 2 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Squalene monooxygenase inhibitor 2-[[3-[[[(E)-6,6-dimethylhept... 4 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Histamine H3 receptor ligand (NE)-N-[2-[2-(dimethylamino)ethox... 3 2
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-000I3M family 2 6
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BF6 family 1 1
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1
Putative NP ZINC04061066 Family 18 0
Putative NP ZINC04026929 Family 4 0
Putative NP ZINC38201335 Family 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00179772 CHEMBL212222 Bioactive SureCN14287736
CFAMM00179759 CHEMBL2413832 Bioactive SureCN4083892
CFAMM00179789 CHEMBL2413824 Bioactive AGN-PC-00IL2L
CFAMM00179830 CHEMBL139578 Bioactive AGN-PC-075NG2
CFAMM00179781 CHEMBL240250 Bioactive AGN-PC-00R7WK
CFAMM00179808 CHEMBL397065 Bioactive SureCN1035039
CFAMM00179761 CHEMBL2413837 Bioactive SureCN3575578
CFAMM00179829 CHEMBL210908 Bioactive SureCN5100620
CFAMM00179760 CHEMBL2413835 Bioactive SureCN4100285
CFAMM00179816 DNC000020 Investigative Drug (Z)-3-[2-(9H-fluoren-2-yloxy)ethylidene]-quinuclidine hydrochloride 31

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48692 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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