CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID806
Family Name Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-isoquinolin-1-yl)-guanidine Family
No. of Seeds 4 No. of Other Members 37
Family Centroid CFAMM00218974 Functional Category Investigative Drug
Superfamily Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-isoquinolin-1-yl)-guanidine Superfamily
Class Class 513

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(4-f... 2 5
Reverse transcriptase Inhibitor PT-115 Family 7 19
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
Reverse transcriptase/RNaseH inhibitor AC1MHDM5 family 2 0
Translocator protein inhibitor SureCN6906757 family 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4... 13 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Renin inhibitor SureCN6042213 family 2 3
Glucocorticoid receptor ligand SureCN3894124 family 3 0
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Coagulation factor X inhibitor JTV-803 free base family 4 7
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0
Macrophage migration inhibitory factor homologue inhibitor 4-[... 2 1
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
TGF-beta receptor type-1 ligand 2wou family 1 0
Huntingtin and Nuclear receptor ROR-gamma ligand CHEMBL1324975... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00218974 DNC004619 Investigative Drug N-(7-Benzyloxy-isoquinolin-1-yl)-guanidine
CFAMM00218986 DNC004630 Investigative Drug N-(5-Benzyloxy-isoquinolin-1-yl)-guanidine
CFAMM00218992 DNC002855 Investigative Drug 3-(Benzyloxy)Pyridin-2-Amine
CFAMM00218977 DNC002860 Investigative Drug 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27257 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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