CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID823
Family Name Macrophage metalloelastase Inhibitor PF-00356231 Family
No. of Seeds 5 No. of Other Members 79
Family Centroid CFAMM00219198 Functional Category Investigative Drug with Natural Product
Superfamily Macrophage metalloelastase Inhibitor PF-00356231 Superfamily
Class Class 1827

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Farnesyltransferase beta subunit, putative Inhibitor AZD3409 F... 2 2
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Integrin beta-3 Inhibitor L-739758 Family 2 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Transient receptor potential cation channel subfamily V member... 6 23
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Cholecystokinin receptor type A ligand A-65186 family 2 6
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
Platelet-activating factor receptor ligand YM-461 family 1 11
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 11
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Coagulation factor X inhibitor AGN-PC-030DHH family 1 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 1 2
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-01UBV6 f... 2 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 1
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 1 1
Metabotropic glutamate receptor 5 ligand 2-(2-pyridin-3-ylethy... 1 2
Thromboxane-A synthase inhibitor SureCN9825871 family 6 3
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[5-[[... 1 0
1-(thiophen-2-yl)-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00219236 CHEMBL185782 Bioactive AGN-PC-075GGR
CFAMM00219150 CHEMBL27796 Bioactive 3-[[2-[[5-(benzylcarbamoylamino)thiophene-3-carbonyl]amino]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00219240 CHEMBL132588 Bioactive SureCN6780679
CFAMM00219203 CHEMBL336615 Bioactive SureCN6777049
CFAMM00219198 DNC002893 Investigative Drug PF-00356231

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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