CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID829
Family Name Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine Family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00219324 Functional Category Investigative Drug
Superfamily Aurora kinase B and Aurora kinase A Inhibitor CYC116 Superfamily
Class Class 817

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Reverse transcriptase Inhibitor LY-73497 Family 14 5
Reverse transcriptase Inhibitor HI-443 Family 1 0
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Platelet-activating factor receptor ligand Foropafant family 2 0
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Vascular endothelial growth factor receptor 2 ligand AC1NS6KZ ... 1 0
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 2-(4-hydroxy... 2 15
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Methionine aminopeptidase 2 inhibitor SureCN5376630 family 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Nuclear receptor ROR-gamma and Lysine-specific demethylase 4E ... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075XWO family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00219324 DNC002906 Investigative Drug 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine
CFAMM00219321 DNC012357 Investigative Drug 1-(2-Pyridin-2-yl-ethyl)-3-thiazol-2-yl-thiourea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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