CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID832
Family Name Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine Family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00219360 Functional Category Investigative Drug with Natural Product
Superfamily Cyclin-dependent kinase 2 and Methylated-DNA--protein-cysteine methyltransferase Binder Superfamily
Class Class 1696

Cousin Family NamesSeedsMembers
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Cyclin-dependent kinase 2 Inhibitor 2-anilino-6-cyclohexylmeth... 4 13
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Glucagon receptor ligand SureCN2647807 family 3 7
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Neuropeptide Y receptor type 5 ligand 7-methoxy-2-methyl-6-phe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00219360 DNC002921 Investigative Drug 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE
CFAMM00219359 DNC002909 Investigative Drug 1-Amino-6-Cyclohex-3-Enylmethyloxypurine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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