CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID854
Family Name Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-methyl Ketone Family
No. of Seeds 49 No. of Other Members 348
Family Centroid CFAMM00219892 Functional Category Investigative Drug with Natural Product
Superfamily Cruzipain and Cathepsin S Binder Superfamily
Class Class 1195

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Ezatiostat family 1 4
Flovagatran family 12 546
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Prothrombin Inhibitor Efegatran Family 9 47
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl ... 11 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Epidermal growth factor receptor Ligand (s)-benzyl 4-chloro-3-... 1 0
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 1 24
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Caspase-3 and Caspase-1 inhibitor (4S)-5-[[(2S)-1-[[(3S)-2-hyd... 1 2
Renin inhibitor benzyl N-[3-[[(2S,4S,5S)-6-cyclohexyl-4-hydrox... 2 0
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(2-th... 2 5
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 10 4
Cathepsin S inhibitor SureCN6857538 family 2 12
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(4-me... 2 9
Prolyl endopeptidase and Chymotrypsin-like elastase family mem... 3 9
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Neutrophil elastase inhibitor benzyl N-[2-(4-aminophenyl)-6-ox... 4 23
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Neutrophil elastase inhibitor SureCN7276766 family 3 6
Neutrophil elastase inhibitor SureCN7276506 family 2 7
Neutrophil elastase and Chymotrypsin-C inhibitor benzyl N-[6-(... 3 6
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-3-(3-flu... 2 3
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Caspase-1 inhibitor (3S)-5-(3,3-diphenylpropanoyloxy)-3-[[(2S)... 3 6
Caspase-1 inhibitor (3S)-5-[[(3aS,7aS)-2-oxo-3a,4,5,6,7,7a-hex... 3 0
Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl... 4 27
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 1 0
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 2 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Neutrophil elastase inhibitor benzyl 2-[2,4,8-trioxo-7-[2-oxo-... 2 2
Pol polyprotein inhibitor AC1LA6RA family 4 12
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Cathepsin S inhibitor SureCN7397817 family 9 4
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Prolyl endopeptidase inhibitor benzyl (1R,2S)-2-[(2S)-2-formyl... 2 2
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-4-methyl... 8 22
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Neutrophil elastase inhibitor benzyl N-[(2S)-3-methyl-1-[(2S)-... 2 0
Pol polyprotein inhibitor AC1LADQG family 7 1
Pol polyprotein inhibitor methyl (2S)-2-[[(2S,3R)-2-[[1-[(2R,3... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN7463098 ... 1 0
Caspase-8 and Caspase-9 inhibitor 3-[[(2S)-2-[(2,4-dichlorophe... 1 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Cathepsin K and Cathepsin S inhibitor (2,2,4-trimethyl-3-bicyc... 1 0
Pol polyprotein inhibitor MDL 74538 family 11 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 1 4
Cathepsin K and Cathepsin S inhibitor SureCN6197793 family 1 0
Caspase-1 and Caspase-8 inhibitor benzyl (4S,7S,9Z,11aS)-7-ben... 2 0
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 4 6
NS3 inhibitor SureCN14450642 family 4 7
N-acylethanolamine-hydrolyzing acid amidase inhibitor 5-phenyl... 2 11
Dipeptidyl peptidase 4 inhibitor 2-cyanopyrrolidine 21e family 6 7
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 4 7
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Cathepsin S inhibitor (2R)-N-[(1R)-2-[(4-chlorophenyl)methoxy]... 2 0
Proteasome subunit beta type-5 and Proteasome subunit beta typ... 1 0
Neutrophil elastase inhibitor 1-O-benzyl 4-O-ethyl (3aS,6R,6aR... 3 4
Renin inhibitor AGN-PC-076HPD family 1 0
Cysteine protease and Cruzipain inhibitor ethyl (2S,3R)-3-[(2S... 1 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 0
Neutrophil elastase inhibitor SureCN7273831 family 2 2
Neprilysin inhibitor benzyl (2S)-2-[[2-(sulfanylmethyl)-3,4-di... 4 0
Protease inhibitor AC1O54RX family 2 4
Prothrombin inhibitor (2S,4R)-1-[(2R)-2-amino-3-phenylpropanoy... 4 4
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor [4-[[2-[[4-... 2 1
Pol polyprotein inhibitor AC1LA3C0 family 2 18
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
C-C chemokine receptor type 5 ligand AC1LAKN8 family 4 5
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Pol polyprotein inhibitor benzyl N-[(2R)-1-[[(1S)-1-[(2R,3S)-3... 3 1
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Calpain-1 catalytic subunit inhibitor (4-nitrophenyl)methyl N-... 1 13
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Neutrophil elastase inhibitor 4-[(E)-3-[[(2S)-3-methyl-1-oxo-1... 2 6
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Melanin-concentrating hormone receptor 1 ligand 2-(3,4-difluor... 4 0
Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0
Cathepsin D and Beta-secretase 1 inhibitor benzyl 3-[[(2R,3S)-... 1 0
Legumain-like protease inhibitor tert-butyl 4-[[(2R)-1-[[(2S)-... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor (2R)-N-[... 2 2
Solute carrier family 12 member 5 inhibitor AGN-PC-07ZCLM family 1 12
Tissue alpha-L-fucosidase inhibitor AGN-PC-074YKC family 1 0
Cathepsin B inhibitor AC1LD7MA family 1 0
Beta-lactamase inhibitor SureCN7195773 family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[3-[3-[3... 5 9
Urokinase-type plasminogen activator and Plasminogen inhibitor... 2 1
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Substance-P receptor ligand (3,5-dimethylphenyl)methyl (2S)-2-... 1 2
Disintegrin and metalloproteinase domain-containing protein 10... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 1 0
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-073KRZ family 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 1-... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 5
Cathepsin B and Cathepsin L1 inhibitor benzyl (2S)-2-benzyl-3-... 1 0
Cysteine protease inhibitor ethyl (E,4S)-4-[[(2S)-2-[(2-methyl... 2 0
Furin inhibitor benzyl N-[(5S)-6-[[(2S)-1-[[(2S)-1-[(4-carbami... 1 0
Neprilysin and Endothelin-converting enzyme 1 inhibitor 2-[[2-... 1 0
Calpain-1 catalytic subunit inhibitor benzyl N-[1-[[(2R)-1-bis... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 1 1
Caspase-1 inhibitor benzyl N-[(3R,6S,9aR)-3-[[(3S)-2-hydroxy-5... 1 0
(4R,5S)-4-methyl-5-phenyl-1,3-oxazolidin-2-one NP (4r,5s)-4-me... 1 4
NP (r)-((2r,3s,4r,5r,6s)-3,4,5,6-tetrahydroxytetrahydro-2h-pyr... 8 4
pyrrolidine-1,2-dicarboxylate NP ZINC04028685 Family 2 3
N'-[[4-(4-methoxyphenyl)oxan-4-yl]methyl]-N-[(1-phenylcyclopen... 1 1
NP (3r,7r,8as)-3-benzyl-1,4-dioxooctahydropyrrolo[1,2-a]pyrazi... 2 3
NP (s)-methyl 2-(5-(benzyloxy)-4-oxo-4h-pyran-2-carboxamido)pr... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00219770 CHEMBL110685 Bioactive benzyl N-[(2S)-1-[(2S)-2-[[(3S)-6-(butoxycarbonylamino)-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00219834 CHEMBL1651351 Bioactive benzyl N-[(2S,3S)-1-[[cyano(methyl)amino]-methylamino]-3-methyl-1-oxopentan-2-yl]carbamate
CFAMM00219927 CHEMBL151521 Bioactive benzyl N-[(2S)-3,3-dimethyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]carbamate
CFAMM00219688 CHEMBL131319 Bioactive AGN-PC-075L9G
CFAMM00219898 CHEMBL133106 Bioactive AGN-PC-075LB4
CFAMM00219668 CHEMBL1651241 Bioactive benzyl N-[(2S)-1-[[cyano(methyl)amino]-methylamino]-1-oxopropan-2-yl]carbamate
CFAMM00219681 CHEMBL131866 Bioactive AGN-PC-075L3E
CFAMM00219862 CHEMBL576557 Bioactive ethyl (E)-4-[(2-amino-2-oxoethyl)-[[(2S,3S)-3-methyl-2-[[(2R)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoyl]amino]amino]-4-oxobut-2-enoate
CFAMM00219708 CHEMBL131879 Bioactive AGN-PC-075LA2
CFAMM00219776 CHEMBL345338 Bioactive benzyl N-[(2S)-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]carbamate
CFAMM00219853 CHEMBL337635 Bioactive AGN-PC-075LAN
CFAMM00219622 CHEMBL354883 Bioactive benzyl N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate
CFAMM00219883 CHEMBL116863 Bioactive AGN-PC-074ZX4
CFAMM00219721 CHEMBL1079410 Bioactive benzyl N-[(2S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]carbamate
CFAMM00219825 CHEMBL130345 Bioactive AGN-PC-075L5E
CFAMM00219904 CHEMBL166401 Bioactive methyl (3S)-4-methyl-3-[[(2S)-1-[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]-2-oxopentanoate
CFAMM00219831 CHEMBL92708 Bioactive calpeptin
CFAMM00219810 CHEMBL134508 Bioactive AGN-PC-075LBG
CFAMM00219587 CHEMBL608115 Bioactive benzyl N-[(2S)-1-[[cyano(methyl)amino]-methylamino]-4-methyl-1-oxopentan-2-yl]carbamate
CFAMM00219851 CHEMBL114388 Bioactive PS-III
CFAMM00219635 CHEMBL130107 Bioactive AGN-PC-00GEI0
CFAMM00219712 CHEMBL134121 Bioactive AGN-PC-075L6G
CFAMM00219650 CHEMBL424550 Bioactive benzyl N-[(2S)-1-[(2S)-2-[[(3S)-1-amino-4-methyl-1,2-dioxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00219909 CHEMBL336649 Bioactive AGN-PC-075L3B
CFAMM00219613 CHEMBL493039 Bioactive AGN-PC-076M0O
CFAMM00219809 CHEMBL2371036 Bioactive benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxobutan-2-yl]amino]pentan-2-yl]carbamate
CFAMM00219994 CHEMBL150600 Bioactive benzyl N-[(2S)-4-methyl-1-[[(2S)-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamate
CFAMM00219619 CHEMBL336171 Bioactive benzyl N-[(2S)-1-oxo-1-[[(2S)-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]propan-2-yl]amino]propan-2-yl]carbamate
CFAMM00219843 CHEMBL162175 Bioactive piperidinone analogue, 28
CFAMM00219642 CHEMBL306203 Bioactive tert-butyl N-[(4S)-2,2-difluoro-5-methyl-4-[[(2S)-1-[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxohexyl]carbamate
CFAMM00219657 CHEMBL334744 Bioactive AGN-PC-075LAC
CFAMM00219605 CHEMBL357595 Bioactive benzyl N-[(2S)-1-[[(2R)-4-methyl-1-[[(2R)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]carbamate
CFAMM00219670 CHEMBL1651242 Bioactive benzyl N-[(2S)-1-[[cyano(methyl)amino]-methylamino]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00219683 CHEMBL99195 Bioactive Z-Leu-met-H
CFAMM00219771 CHEMBL134002 Bioactive Calpain Inhibitor XI
CFAMM00219689 CHEMBL356841 Bioactive AC1L9UW6
CFAMM00219807 CHEMBL131264 Bioactive AGN-PC-075L4Z
CFAMM00219906 DNC005906 Investigative Drug N-(benzyloxycarbonyl)-leucyl-glycine-nitrile
CFAMM00219892 DNC002960 Investigative Drug Benzoyl-Arginine-Alanine-Methyl Ketone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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