CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID856
Family Name Cruzipain Inhibitor WRR-204 Family
No. of Seeds 18 No. of Other Members 35
Family Centroid CFAMM00220158 Functional Category Investigative Drug
Superfamily Cruzipain and Cathepsin S Binder Superfamily
Class Class 1195

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Ezatiostat family 1 4
Flovagatran family 12 546
Prothrombin Inhibitor Efegatran Family 9 47
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl ... 11 5
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Cathepsin D and Beta-secretase 1 inhibitor tert-butyl N-[(2S)-... 1 0
Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(2-th... 2 5
Cathepsin S inhibitor SureCN6857538 family 2 12
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(4-me... 2 9
Prolyl endopeptidase and Chymotrypsin-like elastase family mem... 3 9
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Cathepsin K and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-3-... 1 0
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-3-(3-flu... 2 3
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Caspase-1 inhibitor (3S)-5-(3,3-diphenylpropanoyloxy)-3-[[(2S)... 3 6
Caspase-1 inhibitor (3S)-5-[[(3aS,7aS)-2-oxo-3a,4,5,6,7,7a-hex... 3 0
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Cathepsin S inhibitor SureCN7397817 family 9 4
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Neutrophil elastase inhibitor benzyl N-[(2S)-3-methyl-1-[(2S)-... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Pol polyprotein inhibitor Sulfone deriv. 31 family 15 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Melanin-concentrating hormone receptor 1 ligand SureCN7463098 ... 1 0
Pol polyprotein inhibitor MDL 74538 family 11 1
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Beta-secretase 1 and Cathepsin B inhibitor SureCN4666465 family 9 4
Cathepsin S inhibitor (2R)-N-[(1R)-2-[(4-chlorophenyl)methoxy]... 2 0
Proteasome subunit beta type-5 and Proteasome subunit beta typ... 1 0
Neutrophil elastase inhibitor 1-O-benzyl 4-O-ethyl (3aS,6R,6aR... 3 4
Renin inhibitor AGN-PC-076HPD family 1 0
Cysteine protease and Cruzipain inhibitor ethyl (2S,3R)-3-[(2S... 1 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Neprilysin inhibitor benzyl (2S)-2-[[2-(sulfanylmethyl)-3,4-di... 4 0
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Protease inhibitor AC1O54RX family 2 4
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor [4-[[2-[[4-... 2 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Pol polyprotein inhibitor benzyl N-[(2R)-1-[[(1S)-1-[(2R,3S)-3... 3 1
Pol polyprotein inhibitor AC1LACBC family 2 0
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor (2R)-N-[... 2 2
Cathepsin B inhibitor AC1LD7MA family 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Caspase-3 and Caspase-7 inhibitor valine aspartyl ketone 16 fa... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 1-... 1 0
Cysteine protease inhibitor ethyl (E,4S)-4-[[(2S)-2-[(2-methyl... 2 0
Furin inhibitor benzyl N-[(5S)-6-[[(2S)-1-[[(2S)-1-[(4-carbami... 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00220190 CHEMBL31788 Bioactive SureCN7443679
CFAMM00220161 CHEMBL161508 Bioactive benzyl N-[(2S)-1-[[(2S)-4-cyclohexylsulfanyl-3-oxo-1-phenylbutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00220176 CHEMBL100849 Bioactive benzyl N-[(2S)-1-oxo-1-[[(2S)-3-oxo-1-phenyl-4-(2-phenylethylsulfanyl)butan-2-yl]amino]-3-phenylpropan-2-yl]carbamate
CFAMM00220160 CHEMBL161424 Bioactive benzyl N-[(2S)-1-[[(2S)-4-butan-2-ylsulfanyl-3-oxo-1-phenylbutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00220194 CHEMBL103238 Bioactive benzyl N-[(2S)-1-oxo-1-[[(2S)-3-oxo-1-phenyl-4-(3-phenylpropylsulfanyl)butan-2-yl]amino]-3-phenylpropan-2-yl]carbamate
CFAMM00220174 CHEMBL287630 Bioactive SureCN7449383
CFAMM00220187 CHEMBL161573 Bioactive benzyl N-[(2S)-1-oxo-1-[[(2S)-3-oxo-4-(2,2,4,6,6-pentamethylheptan-4-ylsulfanyl)-1-phenylbutan-2-yl]amino]-3-phenylpropan-2-yl]carbamate
CFAMM00220165 CHEMBL162695 Bioactive benzyl N-[(2S)-1-oxo-1-[[(2S)-3-oxo-1-phenyl-4-propan-2-ylsulfanylbutan-2-yl]amino]-3-phenylpropan-2-yl]carbamate
CFAMM00220193 CHEMBL96185 Bioactive AC1LALPZ
CFAMM00220171 CHEMBL161739 Bioactive ethyl 3-[(3S)-3-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-2-oxo-4-phenylbutyl]sulfanylpropanoate
CFAMM00220169 CHEMBL258808 Bioactive benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-3-oxo-1-phenyl-4-propan-2-ylsulfanylbutan-2-yl]amino]pentan-2-yl]carbamate
CFAMM00220158 DNC002963 Investigative Drug WRR-204

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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