CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID858
Family Name Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxyphenoxy)-2,4-quinazolinediamine Family
No. of Seeds 5 No. of Other Members 61
Family Centroid CFAMM00220218 Functional Category Investigative Drug with Natural Product
Superfamily Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Binder Superfamily
Class Class 685

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Tyrosine kinase Inhibitor PKI166 Family 17 198
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 5 Ligand 7-(4,6-dimethoxypyrim... 2 0
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Dihydrofolate reductase inhibitor 7-(5-chloro-2-ethoxyphenyl)-... 2 1
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Methionine--tRNA ligase inhibitor 2-[3-[(3,5-dibromo-2-ethoxyp... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Transient receptor potential cation channel subfamily V member... 2 4
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[(5-fl... 3 2
Transient receptor potential cation channel subfamily V member... 2 0
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 2 2
Heat shock protein HSP 90-alpha inhibitor 4-[2-Chloro-6-(4,4,4... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00220253 CHEMBL1818113 Bioactive 7-(2-methoxyphenyl)quinazoline-2,4-diamine
CFAMM00220285 CHEMBL1528359 Bioactive STK558875
CFAMM00220265 CHEMBL1818118 Bioactive 7-(2-ethoxyphenyl)quinazoline-2,4-diamine
CFAMM00220262 DNC008106 Investigative Drug 5-(2-fluorobenzyloxy)quinazoline-2,4-diamine
CFAMM00220218 DNC002966 Investigative Drug 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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