CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Peptide deformylase, mitochondrial Inhibitor 5-phenylsulfanyl-2,4-quinazolinediamine Family
No. of Seeds 5 No. of Other Members 23
Family Centroid CFAMM00220307 Functional Category Investigative Drug
Superfamily Peptide deformylase, mitochondrial and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 1843

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Histamine H4 receptor Ligand A-943931 Family 14 11
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Dihydrofolate reductase inhibitor 6-(3,4-dichlorophenyl)sulfan... 1 0


External ID

Functional Category

Molecule Name

CFAMM00220318 CHEMBL6975 Bioactive 5-(naphthalen-2-ylsulfanylmethyl)quinazoline-2,4-diamine
CFAMM00220323 CHEMBL329985 Bioactive TQ5
CFAMM00220333 CHEMBL157652 Bioactive 5-naphthalen-2-ylsulfanylquinazoline-2,4-diamine
CFAMM00220320 DNC012703 Investigative Drug 5-p-Tolylsulfanyl-quinazoline-2,4-diamine
CFAMM00220307 DNC002967 Investigative Drug 5-Phenylsulfanyl-2,4-Quinazolinediamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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