CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID885
Family Name Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-methyl-chromen-2-one Family
No. of Seeds 4 No. of Other Members 59
Family Centroid CFAMM00221383 Functional Category Investigative Drug with Natural Product
Superfamily NAD(P)H dehydrogenase [quinone] 1 and Peptidyl-prolyl cis-trans isomerase A Binder Superfamily
Class Class 1859

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Histamine H1 receptor and Histamine H3 receptor Ligand GSK8357... 2 2
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
Aromatase Inhibitor 3,5-diacetoxy-4'-amino-trans-stilbene Family 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Glucosylceramidase inhibitor 7-(diethylamino)-N-[[(2R,4S,5R)-3... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Androgen receptor ligand (6R,7R)-6,7-diethyl-4-(trifluoromethy... 15 20
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
Sodium/bile acid cotransporter and Glucocorticoid receptor lig... 4 8
Acetylcholinesterase and Cholinesterase inhibitor [3-[4-(3,4-d... 3 18
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(2-ethylsulfonyl... 5 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Androgen receptor ligand 10-(hydroxymethyl)-4-methyl-1,5-dihyd... 2 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Bifunctional epoxide hydrolase 2 inhibitor [3-(1-adamantylcarb... 1 0
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 2 0
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Cathepsin K and Cathepsin B inhibitor N-[1-[[cyano(methyl)amin... 1 1
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Multidrug resistance protein 1 inhibitor UNII-05D072FS97 family 1 3
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Progesterone receptor ligand 7-(diethylamino)-6-(4-nitrophenyl... 2 0
NAD-dependent protein deacetylase sirtuin-2 inhibitor 2-[3-[2-... 1 0
(5S)-5-methyl-3-(2-oxochromen-7-yl)imidazolidine-2,4-dione NP ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00221404 CHEMBL138072 Bioactive trimethyl-(4-methyl-3-propanoyloxyphenyl)azanium
CFAMM00221358 CHEMBL139330 Bioactive AGN-PC-075N9K
CFAMM00221383 DNC003024 Investigative Drug 7-AMINO-4-METHYL-CHROMEN-2-ONE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27619 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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