CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID897
Family Name Thymidylate synthase Inhibitor Sp-876 Family
No. of Seeds 7 No. of Other Members 117
Family Centroid CFAMM00221594 Functional Category Investigative Drug with Natural Product
Superfamily Thymidylate synthase Inhibitor Sp-876 Superfamily
Class Class 1866

Cousin Family NamesSeedsMembers
ATP-sensitive inward rectifier potassium channel 10 Ligand Ace... 2 64
Iofolastat I-124 family 6 33
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Integrin beta-3 Inhibitor L-750034 Family 7 38
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-137546 Family 1 3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Pol polyprotein inhibitor Lysine Sulfonamide 11t family 1 4
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6016173 f... 10 15
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6368512 f... 23 21
Integrin beta-1 and Integrin alpha-4 inhibitor (3R)-3-[[(2S)-1... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (3R)-3-[[(2S)-1... 3 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686807 f... 7 2
Pol polyprotein inhibitor AC1LAHQ3 family 13 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Angiotensin-converting enzyme inhibitor (2S)-2-[[(2S)-1-[carbo... 2 5
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(benze... 2 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-3-[[3-ox... 2 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Carbonic anhydrase 2 inhibitor benzyl 2-[[2-[[(2S)-3-phenyl-2-... 2 9
Carbonic anhydrase 2 inhibitor 4-sulfamoyl-N-[2-[2-[2-[[(2R)-2... 5 1
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[car... 1 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 9
4-methyl-2-[[(E)-3-phenylprop-2-enyl]azaniumyl]pentanoate NP 2... 4 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00221526 CHEMBL152471 Bioactive AGN-PC-073RP7
CFAMM00221540 CHEMBL51346 Bioactive 2-[[(2S)-4-methyl-2-[(4-sulfamoylbenzoyl)amino]pentanoyl]amino]acetic acid
CFAMM00221616 CHEMBL358443 Bioactive AGN-PC-073RKK
CFAMM00221554 CHEMBL152298 Bioactive AGN-PC-075SUE
CFAMM00221608 CHEMBL153748 Bioactive AGN-PC-075SUC
CFAMM00221591 DNC003059 Investigative Drug Sp-722
CFAMM00221594 DNC003057 Investigative Drug Sp-876

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27425 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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