CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Trifunctional purine biosynthetic protein adenosine-3 Inhibitor 10-formyl-5,8,10-trideazafolic Acid Family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00222104 Functional Category Investigative Drug
Superfamily Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Superfamily
Class Class 617

Cousin Family NamesSeedsMembers
Thymidylate synthase Inhibitor Raltitrexed Family 1 15
Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Family 9 83
Dihydroorotase, putative Inhibitor 5-amino Orotate Family 2 4
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Estrogen receptor and Thymidylate synthase ligand (2R)-2-[[(4S... 1 1
Glycogen phosphorylase, liver form inhibitor SureCN5195475 family 9 5
Glycogen phosphorylase, liver form inhibitor AGN-PC-00CDLB family 2 0
Transmembrane protease serine 11D and Suppressor of tumorigeni... 1 3


External ID

Functional Category

Molecule Name

CFAMM00222102 CHEMBL104230 Bioactive (2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]pentanedioic acid
CFAMM00222104 DNC003084 Investigative Drug 10-Formyl-5,8,10-Trideazafolic Acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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