CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID929
Family Name Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)phenyl]-l-glutamamide Family
No. of Seeds 7 No. of Other Members 49
Family Centroid CFAMM00222468 Functional Category Investigative Drug with Natural Product
Superfamily Leukotriene A-4 hydrolase Binder Superfamily
Class Class 1884

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Cyclooxygenase Inhibitor Acetaminophen Family 2 42
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Substance-P receptor Ligand Ezlopitant Family 10 207
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 2 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor 2-(benzyloxy)-n7-hydroxy-n1-ph... 1 3
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 10 9
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 2 0
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Capsid scaffolding protein inhibitor AC1LAC6N family 2 1
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Melanin-concentrating hormone receptor 1 ligand 1-[1-(1-methyl... 5 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
2-acylglycerol O-acyltransferase 2 inhibitor N-(4-methoxypheny... 1 0
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Substance-P receptor ligand CP 141938 family 1 0
Neutrophil elastase inhibitor AGN-PC-04S1IE family 1 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-acety... 6 7
D(3) dopamine receptor ligand rac S 33138 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Lysophosphatidic acid receptor 2 and Lysophosphatidic acid rec... 1 0
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
fMet-Leu-Phe receptor ligand 2-[[(2S)-2-[[(2S)-2-[(4-methoxyph... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN8058778 family 13 4
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 0
Excitatory amino acid transporter 2 and Excitatory amino acid ... 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 7
Adenosine receptor A3 ligand N-(4-methoxyphenyl)-2-oxo-1H-quin... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Methionine aminopeptidase 2 and Methionine aminopeptidase 1 in... 1 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
1-(3-methoxyphenyl)-5-oxo-N-(2-oxochromen-6-yl)pyrrolidine-3-c... 2 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
Putative NP ZINC04043041 Family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00222483 DNC008552 Investigative Drug N5-[4-(4-methylphenoxy)phenyl]-L-glutamamide
CFAMM00222453 DNC003140 Investigative Drug 4-amino-N-[4-(benzyloxy)phenyl]butanamide
CFAMM00222482 DNC008555 Investigative Drug 4S-4,5-Diamino-N-(4-phenoxyphenyl)pentanamide
CFAMM00222481 DNC008554 Investigative Drug N5-[4-(2-methylphenoxy)phenyl]-L-glutamamide
CFAMM00222468 DNC008541 Investigative Drug N5-[4-(Phenylmethoxy)phenyl]-L-glutamamide
CFAMM00222466 DNC003139 Investigative Drug N-[4-(benzyloxy)phenyl]glycinamide
CFAMM00222484 DNC008553 Investigative Drug N5-[4-(3-methylphenoxy)phenyl]-L-glutamamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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