CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID947
Family Name Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thiophen-3-ylphenyl)ethyl)-1h-imidazole Family
No. of Seeds 3 No. of Other Members 36
Family Centroid CFAMM00222718 Functional Category Investigative Drug
Superfamily Aromatase and Steroid 17-alpha-hydroxylase/17,20 lyase Binder Superfamily
Class Class 1896

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
14-alpha sterol demethylase Inhibitor Butoconazole Family 2 53
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor 1-(2-(benzo[b]thiophen-4-yl)ethyl)-1h-imid... 1 1
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
NADH-ubiquinone oxidoreductase chain 3 Inhibitor 6-thiophen-3-... 2 0
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 4
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-00FW8Y family 1 1
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 1 1
Dopamine beta-hydroxylase inhibitor SureCN10690669 family 3 4
Dopamine beta-hydroxylase inhibitor AGN-PC-002JYF family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00222751 DNC003182 Investigative Drug 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole
CFAMM00222718 DNC008203 Investigative Drug 1-(1-(4-thiophen-3-ylphenyl)ethyl)-1H-imidazole
CFAMM00222717 DNC008204 Investigative Drug 1-(1-(4-thiophen-3-yl-phenyl)propyl)-1Himidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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