CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID953
Family Name Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dione Family
No. of Seeds 10 No. of Other Members 35
Family Centroid CFAMM00222933 Functional Category Investigative Drug with Natural Product
Superfamily Liver carboxylesterase 1 and Amine oxidase [flavin-containing] A Binder Superfamily
Class Class 1900

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Glutamate receptor ionotropic, NMDA 1 Ligand Dcka, 5,7-dichlor... 2 7
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 4-methyl-5,6... 3 12
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Cruzipain Inhibitor 5-chloro-1-(4-chloro-benzyl)-1h-indole-2,3... 3 13
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
MO15-related protein kinase Pfmrk Inhibitor 5-nitro-1h-indole-... 1 4
Fatty acid-binding protein and C-X-C chemokine receptor type 1... 1 6
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Transient receptor potential cation channel subfamily V member... 6 33
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Liver carboxylesterase 1 Inhibitor 6-bromo-5-methyl-1h-indole-... 1 0
Liver carboxylesterase 1 Inhibitor 4-chloro-1h-indole-2,3-dion... 3 7
Liver carboxylesterase 1 Inhibitor 7-chloro-1h-indole-2,3-dion... 6 5
Liver carboxylesterase 1 Inhibitor 7-(trifluoromethyl)-1h-indo... 1 1
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
M-phase inducer phosphatase 1 Inhibitor (z)-2-(1-decyl-2-oxoin... 2 2
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M5 Ligand VU0119498 Family 1 3
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Amyloid beta A4 protein inhibitor AGN-PC-08WTQK family 1 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Prelamin-A/C and Beta-lactamase inhibitor AE-562/12222510 family 1 9
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 11
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
Acetylcholinesterase inhibitor tmtfa family 1 2
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Telomerase reverse transcriptase inhibitor AGN-PC-07ZBGW family 2 0
Transient receptor potential cation channel subfamily A member... 1 0
Cytochrome P450 2C19 and 3-hydroxyacyl-CoA dehydrogenase type-... 1 5
4,4,6,9-tetramethyl-6-phenyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]q... 5 1
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00222917 DNC007184 Investigative Drug 1-propionyl-1H-indole-2,3-dione
CFAMM00222916 DNC007183 Investigative Drug 1-butyryl-1H-indole-2,3-dione
CFAMM00222933 DNC007178 Investigative Drug 1-methyl-1H-indole-2,3-dione
CFAMM00222915 DNC007181 Investigative Drug 1-benzyl-1H-indole-2,3-dione
CFAMM00222913 DNC007188 Investigative Drug 1-dodecyl-1H-indole-2,3-dione
CFAMM00222920 DNC007187 Investigative Drug 1-hexadecyl-1H-indole-2,3-dione
CFAMM00222937 DNC003201 Investigative Drug Isatin
CFAMM00222919 DNC007186 Investigative Drug 1-(2-bromoethyl)-1H-indole-2,3-dione
CFAMM00222900 DNC003700 Investigative Drug 1-(3,3-Dimethyl-2-oxo-butyl)-1H-indole-2,3-dione
CFAMM00222918 DNC007185 Investigative Drug 1-(2-iodoethyl)-1H-indole-2,3-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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