CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID958
Family Name Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit gamma-2 Ligand 3-ethoxy-9h-beta-carboline Family
No. of Seeds 13 No. of Other Members 22
Family Centroid CFAMM00223594 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Melatonin receptor type 1A Ligand Melatonin Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Apricoxib family 8 77
Indeglitazar family 3 39
Grt 6005/06 family 4 22
PF-02545920 family 16 140
8-aminoquinoline Inhibitor Tafenoquine Family 1 0
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Tyrosine kinase Inhibitor PKI166 Family 17 198
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Glycogen synthase kinase-3 beta Inhibitor 9-n-ethyl-8-ethoxy-m... 3 0
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
Transient receptor potential cation channel subfamily V member... 2 12
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 1
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
Transient receptor potential cation channel subfamily V member... 2 4
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Transient receptor potential cation channel subfamily V member... 6 1
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Glucagon receptor ligand SureCN2647807 family 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Nischarin inhibitor SureCN7810370 family 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Tyrosine-protein kinase ITK/TSK inhibitor N-[(3Z)-3-(6-methoxy... 2 4
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Transient receptor potential cation channel subfamily V member... 3 2
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
DNA gyrase subunit B and DNA gyrase subunit A inhibitor (1S,2R... 4 6
C-X-C chemokine receptor type 2 ligand 4-[5-cyano-2-(4-fluorop... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit alpha inhib... 1 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Vascular endothelial growth factor receptor 2 ligand (2Z)-2-[[... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0
Histamine H1 receptor and Histamine H2 receptor ligand AGN-PC-... 1 1
Indoles Metabolite 6-Methoxy-3-(2-thiazolyl)-1H-indole Family 1 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
Putative NP ZINC20112899 Family 6 0
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium NP ZINC02119030... 14 0
oxo-[4-[(E)-2-(9H-pyrido[3,4-b]indol-1-yl)ethenyl]phenoxy]azan... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00223587 DNC011653 Investigative Drug 7-Methoxy-9H-beta-carboline
CFAMM00223573 DNC011245 Investigative Drug 3-propoxy-9H-pyrido[3,4-b]indole
CFAMM00223603 DNC011252 Investigative Drug 3-isobutoxy-9H-pyrido[3,4-b]indole
CFAMM00223576 DNC011804 Investigative Drug 3-(2,2-Dimethyl-propoxy)-9H-beta-carboline
CFAMM00223594 DNC004240 Investigative Drug 3-Ethoxy-9H-beta-carboline
CFAMM00223584 DNC003210 Investigative Drug 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE
CFAMM00223600 DNC011250 Investigative Drug 3-(benzyloxy)-9H-pyrido[3,4-b]indole
CFAMM00223599 DNC011821 Investigative Drug 3-sec-Butoxy-9H-beta-carboline
CFAMM00223606 DNC007094 Investigative Drug 6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole
CFAMM00223598 DNC011826 Investigative Drug 3-Isopropoxy-9H-beta-carboline
CFAMM00223605 DNC007092 Investigative Drug 6-methoxy-2,9-dimethyl-9H-beta-carbolin-2-ium
CFAMM00223574 DNC011249 Investigative Drug 3-(isopentyloxy)-9H-pyrido[3,4-b]indole
CFAMM00223604 DNC011251 Investigative Drug 3-butoxy-9H-pyrido[3,4-b]indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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