CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Serine/threonine-protein kinase Chk1 Inhibitor N-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)glycine Family
No. of Seeds 9 No. of Other Members 100
Family Centroid CFAMM00223847 Functional Category Investigative Drug
Superfamily Peptide deformylase, mitochondrial and Serine/threonine-protein kinase Chk1 Binder Superfamily
Class Class 1877

Cousin Family NamesSeedsMembers
MK-6096 family 3 69
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Peptide deformylase, mitochondrial Inhibitor Furo[2,3d]pyrimid... 2 10
5-hydroxytryptamine receptor 2C Ligand 6-methyl-4-(piperazin-1... 1 0
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Dihydrofolate reductase and Trifunctional purine biosynthetic ... 1 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor CHEM... 1 0
Vascular endothelial growth factor receptor 1 and Receptor-typ... 2 11
Vascular endothelial growth factor receptor 1 ligand CHEMBL197... 1 2
Activated CDC42 kinase 1 inhibitor 6-(4-methylsulfonylphenyl)-... 2 0
Activated CDC42 kinase 1 inhibitor 6-[4-(2-morpholin-4-ylethox... 7 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1


External ID

Functional Category

Molecule Name

CFAMM00223788 CHEMBL2087661 Bioactive N,N-dimethyl-4-[4-[[(2S)-oxolan-2-yl]methylamino]-5-phenylfuro[2,3-d]pyrimidin-6-yl]benzamide
CFAMM00223794 CHEMBL2347963 Bioactive 3-(dimethylamino)-N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]propanamide
CFAMM00223840 CHEMBL2087648 Bioactive 6-(4-methoxyphenyl)-N-[[(2S)-oxolan-2-yl]methyl]-5-phenylfuro[2,3-d]pyrimidin-4-amine
CFAMM00223857 CHEMBL247667 Bioactive SureCN2967328
CFAMM00223786 CHEMBL2087665 Bioactive morpholin-4-yl-[4-[4-[[(2S)-oxolan-2-yl]methylamino]-5-phenylfuro[2,3-d]pyrimidin-6-yl]phenyl]methanone
CFAMM00223877 CHEMBL247479 Bioactive SureCN2965891
CFAMM00223875 CHEMBL247677 Bioactive SureCN2965643
CFAMM00223852 CHEMBL1172843 Bioactive SureCN3318183
CFAMM00223847 DNC003252 Investigative Drug N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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