CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Estrogen receptor beta Ligand 1-chloro-6-(4-hydroxyphenyl)-2-naphthol Family
No. of Seeds 12 No. of Other Members 23
Family Centroid CFAMM00223997 Functional Category Investigative Drug
Superfamily Estrogen receptor beta and Arachidonate 15-lipoxygenase Binder Superfamily
Class Class 555

Cousin Family NamesSeedsMembers
Oestrogen receptor ligand steroid Estradiol Family 18 147
Oestrogen receptor ligand Dienestrol Family 35 440
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Oestrogen receptor and Estrogen receptor beta Ligand 1-bromo-6... 3 4
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 1 6
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Estrogen receptor beta and Estrogen receptor ligand (4Z)-2-flu... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 2
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 3


External ID

Functional Category

Molecule Name

CFAMM00223967 CHEMBL191808 Bioactive SureCN3933985
CFAMM00223965 CHEMBL193146 Bioactive SureCN3925187
CFAMM00223962 CHEMBL191901 Bioactive SureCN3934274
CFAMM00223994 CHEMBL363177 Bioactive SureCN3934241
CFAMM00223992 CHEMBL191710 Bioactive SureCN3925608
CFAMM00223971 CHEMBL447837 Bioactive SureCN3933745
CFAMM00223982 CHEMBL192260 Bioactive SureCN3928809
CFAMM00223975 DNC005581 Investigative Drug 1,8-Dichloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00223997 DNC003260 Investigative Drug 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
CFAMM00223974 DNC005580 Investigative Drug 8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00223985 DNC005577 Investigative Drug 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00223983 DNC005573 Investigative Drug 6-(2-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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