CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID98
Family Name Reverse transcriptase Inhibitor 3'thiacytidine Family
No. of Seeds 4 No. of Other Members 29
Family Centroid CFAMM00180985 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Reverse transcriptase and Hemoglobin subunit alpha Binder Superfamily
Class Class 1002

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 4 2
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Transient receptor potential cation channel subfamily V member... 6 1
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-04XS1Y f... 1 4
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Aromatase inhibitor isoflavone deriv. 5m family 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Small conductance calcium-activated potassium channel protein ... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Small conductance calcium-activated potassium channel protein ... 1 1
5-hydroxytryptamine receptor 1A ligand (1S,5R)-8-[[(3S)-5-meth... 2 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... 1 1
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
dimethyl-4-[[4-(2-pyridin-4-ylethyl)piperazin-4-ium-1-yl]methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00181005 CHEMBL1162395 Bioactive 2wn9
CFAMM00181004 DNC000707 Investigative Drug GTS-21
CFAMM00180985 DNC000065 Investigative Drug 3'thiacytidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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