CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID983
Family Name Phospholipase A2 Inhibitor P-anisic Acid Family
No. of Seeds 2 No. of Other Members 178
Family Centroid CFAMM00224164 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Phospholipase A2 and Amine oxidase [flavin-containing] B Binder Superfamily
Class Class 366

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Histamine H1 receptor Ligand Doxepin Family 8 89
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Solute carrier family 12 member 1 Inhibitor Ethacrynic Acid Fa... 3 42
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Serine protease Inhibitor Gabexate Family 1 3
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Prostaglandin G/H synthase 1 Inhibitor (3-chloro-4-propoxy-phe... 2 10
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Epidermal growth factor receptor Ligand AG-538 Family 5 11
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Thyroid hormone receptor beta Ligand (3,5-dibromo-4-pentyloxy-... 5 21
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
Interstitial collagenase Inhibitor N-hydroxy-4-(4-methoxy-phen... 6 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Glutamate carboxypeptidase 2 Inhibitor 3-(1-carboxy-4-mercapto... 1 1
Prostaglandin D2 receptor 2 Ligand 2-(2-benzoyl-4-bromophenoxy... 4 35
Tyrosine-protein phosphatase non-receptor type 1 Ligand Phelli... 1 1
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Protein kinase C delta type and Protein kinase C alpha type In... 4 105
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Aromatase Inhibitor NSC-122427 Family 1 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Neutrophil elastase Inhibitor E-6-o-p-methoxycinnamoyl Scandos... 2 68
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Tyrosyl-DNA phosphodiesterase 1 and Microtubule-associated pro... 1 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Amine oxidase [flavin-containing] B inhibitor 5-(4,4,4-trifluo... 2 9
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Protein kinase C delta type and Protein kinase C beta type inh... 3 9
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
Histone deacetylase 2 and Histone deacetylase 8 inhibitor 2-hy... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Cysteinyl leukotriene receptor 1 ligand 4-[(E)-1-carboxy-6-[4-... 2 9
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Protein kinase C delta type and Protein kinase C alpha type in... 1 10
Glutamate carboxypeptidase 2 inhibitor SureCN5486002 family 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 7
Acetylcholinesterase inhibitor 5,7-Dimethoxy-2-methyl-indan-1-... 1 0
Protein kinase C alpha type inhibitor [(1R)-4-dodecoxy-1-(hydr... 1 18
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Heat shock protein HSP 90-alpha inhibitor Catalposide family 5 22
Cytosolic phospholipase A2 beta inhibitor 5-[3-(4-decoxyphenox... 2 15
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
Putative fructose-1,6-bisphosphate aldolase and Retinal dehydr... 1 0
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
Glycogen phosphorylase, muscle form and Glycogen phosphorylase... 1 2
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
NS5B protein inhibitor AC1LAB50 family 2 1
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
NS5B protein inhibitor SureCN3988565 family 2 4
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Indoleamine 2,3-dioxygenase 1 inhibitor AGN-PC-04S2CP family 1 3
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00OPWJ family 1 1
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Fyn in... 1 2
Integrase inhibitor AC1NX3RZ family 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Benzoxepines Metabolite 4,5-Dihydro-1-benzoxepin-3(2H)-one Family 1 2
Benzofurans Metabolite 4-Hydroxyphthalide Family 1 1
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Prenol Lipids Metabolite Lactupicrin Family 1 0
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Benzofurans Metabolite (R)-Bitalin A Family 1 9
Indenes and Isoindenes Metabolite Coixinden B Family 1 0
Putative NP ZINC31165975 Family 4 0
Putative NP ZINC31158464 Family 3 5
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
Putative NP ZINC04043753 Family 8 6
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
2,5,8-triacetyloxy-3,4-dioxonaphthalen-1-olate NP Agn-pc-094ek... 1 0
4H-1,3-benzodioxine-6-carboxylate NP ZINC07952017 Family 2 2
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
benzofuran-2-one NP 5-hydroxybenzofuran-2(3h)-one Family 1 0
NP 4-(((3-(4-chlorophenyl)-2-methyl-4-oxo-4h-chromen-7-yl)oxy)... 14 0
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
4-acetylphenyl (1'S,2'R,6'R,9'R)-dispiro[cyclohexane-1,4'-[3,5... 4 2
NP 3-(4-methoxyphenoxy)-4-oxo-4h-chromen-7-yl 4-bromobenzoate ... 13 0
NP Agn-pc-05wmi6 Family 2 0
[(2R,3R,4S,5R,6S)-3-acetyloxy-6-[2-(4-methoxyphenyl)-2-oxoethy... 1 1
3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0
NP (z)-2-((2-methyl-2h-chromen-3-yl)methylene)-3-oxo-2,3-dihyd... 74 1
NP (2r,3r,4s,5r,6s)-2-(acetoxymethyl)-6-(2-propionylphenoxy)te... 2 3
4-oxochromene-2-carboxylate NP Ethyl 3-(7-(2-(4-bromophenyl)-2... 10 1
orobenzoate NP 3-(2-methoxyphenyl)-2-methyl-4-oxo-4h-chromen-7... 22 0
5-(4-methoxyphenyl)-2,2-dimethyloxolan-3-one NP 5-(4-methoxyph... 2 0
Putative NP ZINC02424323 Family 24 0
Putative NP ZINC05219435 Family 4 0
ethyl 4-[2-(hydroxyamino)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien... 1 0
bromobenzoate NP ZINC11865066 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224093 DNC007638 Investigative Drug 2-methylbut-3-yn-2-yl 4-methoxybenzoate
CFAMM00224164 DNC003267 Investigative Drug P-Anisic Acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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