CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID986
Family Name Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phenyl-urea Family
No. of Seeds 5 No. of Other Members 65
Family Centroid CFAMM00224301 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Bifunctional epoxide hydrolase 2 Binder Superfamily
Class Class 1917

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Dopamine receptor Ligand Domperidone Family 2 21
Mannose-6-phosphate isomerase Inhibitor Sulfacetamide Family 19 117
Motilin receptor Ligand GSK962040 Family 30 457
Nociceptin receptor Ligand J-113397 Family 3 14
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-(3-p... 7 17
Androgen receptor Ligand YM-175735 Family 30 129
Carbonic anhydrase 2 and Carbonic anhydrase 4 Inhibitor 1-(3,4... 2 9
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Kinesin-like protein KIF11 Inhibitor N-{4'-[(trifluoromethyl)s... 3 1
Kinesin-like protein KIF11 Inhibitor N-(4'-bromo-3,3'-difluoro... 2 0
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Fructose-1,6-bisphosphatase 1 Inhibitor 1-(4-aminophenylsulfon... 2 1
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 2
Tyrosinase Inhibitor 1-hydroxy-3-phenylurea Family 2 10
Tyrosinase Inhibitor 1-(4-bromophenyl)-3-hydroxyurea Family 1 0
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Tyrosinase Inhibitor 1-hydroxy-3-(4-nitrophenyl)urea Family 2 2
Trypsin Inhibitor 1,3-di-p-tolyl-[1,3]diazetidine-2,4-dione Fa... 2 16
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA polymerase Inhibitor 6-(4-bromo-phenylamino)-1h-pyrimidine... 2 1
DNA topoisomerase Inhibitor 6-(3-iodo-phenylamino)-1h-pyrimidi... 2 5
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 3n2p ... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 1-(2-c... 1 1
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 3
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand N-[4-[3... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
5-hydroxytryptamine receptor 2B and Prostaglandin G/H synthase... 1 16
Histone deacetylase 6 and Histone deacetylase 10 inhibitor AGN... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 2 3
Retinal dehydrogenase 1 and Microtubule-associated protein tau... 1 0
Polyamine oxidase inhibitor AGN-PC-07C3XH family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224355 CHEMBL2331759 Bioactive 1-cyclohexyl-3-[4-(sulfamoylamino)phenyl]urea
CFAMM00224384 CHEMBL1818391 Bioactive 1-cyclohexyl-3-(2,3,4-trifluorophenyl)urea
CFAMM00224327 DNC003415 Investigative Drug N-Cyclohexyl-N'-(4-Iodophenyl)Urea
CFAMM00224310 DNC003272 Investigative Drug 1,3-DIPHENYLUREA
CFAMM00224301 DNC005567 Investigative Drug 1-Cyclohexyl-3-phenyl-urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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