CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID997
Family Name Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor Ligand 4-methoxyamphetamine Family
No. of Seeds 5 No. of Other Members 11
Family Centroid CFAMM00224503 Functional Category Investigative Drug with Natural Product
Superfamily Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor Binder Superfamily
Class Class 1226

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 11 21
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 6
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 10
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Dihydrofolate reductase inhibitor 4-[(2,6-diamino-4,5-dihydrop... 2 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... 1 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
D(3) dopamine receptor ligand S 14297 family 1 2
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histone deacetylase 2 and Histone deacetylase 8 inhibitor 2-hy... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Substance-P receptor ligand SureCN6400808 family 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Squalene monooxygenase inhibitor 2-[[3-[[[(E)-6,6-dimethylhept... 4 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 3
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Prostaglandin E synthase inhibitor AGN-PC-09QKN6 family 1 3
Amine oxidase [flavin-containing] A inhibitor AGN-PC-054NIM fa... 1 0
Amine oxidase [flavin-containing] A inhibitor 1-(4-ethylsulfan... 1 1
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 2
Aminopeptidase N inhibitor AGN-PC-07ZVOL family 1 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0A9S9E... 1 0
Acetylcholinesterase and Cholinesterase inhibitor (8E)-4-(2-me... 1 0
N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(4-methoxyphenyl)te... 2 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0
Putative NP ZINC00050501 Family 6 4
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224507 CHEMBL53170 Bioactive SureCN8091471
CFAMM00224500 CHEMBL554775 Bioactive SureCN10722353
CFAMM00224502 DNC009549 Investigative Drug cis-2-Fluoro-2-(4-methoxyphenyl)cyclopropylamine
CFAMM00224503 DNC003316 Investigative Drug 4-Methoxyamphetamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27750 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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