Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
CFAM Family ID CFFID998
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2B Ligand 3,4-methylenedioxymethamphetamine Family
No. of Seeds 3
No. of Other Members 24
Family Centroid CFAMM00224531
Functional Category Investigative Drug with Natural Product
Superfamily Zucapsacin Superfamily
Class Class 725
Cousin Family Names Seeds Members D(2) dopamine receptor ligand catecholamine Dopamine family 9 170 Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209 Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375 Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433 Serotonin re-uptake Inhibitor Fluoxetine Family 18 682 Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29 Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74 Beta adrenergic receptor Ligand Dipivefrin Family 3 55 Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206 Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425 Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56 Alpha adrenergic receptor Ligand Bevantolol Family 4 48 Zucapsacin family 7 177 Endothelin-1 receptor Ligand Atrasentan Family 127 336 Melatonin receptor type 1A Ligand Agomelatine Family 12 164 Substance-P receptor Ligand DA-5018 Family 14 73 D(3) dopamine receptor Ligand U-99194A Family 7 33 Multidrug resistance protein Inhibitor Curcumin I Family 19 278 M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56 Tumor necrosis factor Inhibitor Y-39041 Family 9 51 5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25 Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11 Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36 Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36 5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14 Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3 5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10 Tubulin beta chain Inhibitor Colchinol Family 3 109 5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1 D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10 5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3 Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9 Amine oxidase [flavin-containing] A Inhibitor 2-(4-methoxyphen... 2 7 Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19 Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0 Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4 Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8 Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8 Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26 Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2 Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0 Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1 Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5 Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10 Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2 Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0 Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0 Benzazepines Metabolite N-Methylporphyroxine Family 1 2 NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2 NP (1s,5r,z)-2-(1-((4-methoxybenzyl)amino)ethylidene)-6,6-dime... 4 0 Putative NP ZINC04287792 Family 2 0 Putative NP ZINC00050501 Family 6 4 Putative NP ZINC08453899 Family 3 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00224536
CHEMBL2442146
Bioactive
(2R,4S)-2,4-bis[2-(1,3-benzodioxol-5-yl)ethyl]azetidine;hydrochloride CFAMM00224521
CHEMBL177388
Bioactive
Oprea1_699373 CFAMM00224535
CHEMBL2442143
Bioactive
(2R,4R)-2,4-bis[2-(1,3-benzodioxol-5-yl)ethyl]azetidine;hydrochloride CFAMM00224525
ZINC02131153
Natural Product
[(3S)-3-(1,3-benzodioxol-5-yl)-6-methylheptyl]azanium CFAMM00224540
ZINC32123838
Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[[(4S)-2,2-dimethyloxan-4-yl]azaniumyl]ethyl]azanium CFAMM00224524
ZINC02131154
Natural Product
AC1LWVUE CFAMM00224517
ZINC00206539
Natural Product
AC1LWRNB CFAMM00224530
ZINC04073421
Natural Product
AC1OF2GN CFAMM00224523
ZINC04073419
Natural Product
AC1OF2GH CFAMM00224516
ZINC00170052
Natural Product
3-amino-3-(benzo[d][1,3]dioxol-5-yl)propanoic acid CFAMM00224529
ZINC04073423
Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[(2S,4R)-2-ethyl-2-methyl-4-(3-methylbutyl)oxan-4-yl]ethyl]azanium CFAMM00224522
ZINC02110810
Natural Product
AC1LX5QQ CFAMM00224515
ZINC00170053
Natural Product
(3S)-3-azaniumyl-3-(1,3-benzodioxol-5-yl)propanoate CFAMM00224528
ZINC04073422
Natural Product
AC1OF2GT CFAMM00224527
ZINC02110809
Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[(4R)-2,2-dimethyl-4-(3-methylbutyl)oxan-4-yl]ethyl]azanium CFAMM00224541
ZINC32123839
Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[[(4R)-2,2-dimethyloxan-4-yl]azaniumyl]ethyl]azanium CFAMM00224526
ZINC00206542
Natural Product
1,3-benzodioxol-5-ylmethyl-[(4R)-2,2-dimethyloxan-4-yl]azanium CFAMM00224519
ZINC02144787
Natural Product
3-[acetyl(1,3-benzodioxol-5-ylmethyl)amino]propyl-dimethylazanium CFAMM00224518
585277
Patent Compound
Bis-benzo[1,3]dioxol-5-ylmethyl-amine CFAMM00224538
54113749
Patent Compound
AGN-PC-0A325H CFAMM00224514
56999801
Patent Compound
AGN-PC-0BLW7J CFAMM00224520
4995343
Patent Compound
1,3-BENZODIOXOLE-5-ETHANIMIDAMIDE CFAMM00224513
57252245
Patent Compound
Ethylone CFAMM00224532
738040
Patent Compound
723284-83-1
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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