CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID998
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2B Ligand 3,4-methylenedioxymethamphetamine Family
No. of Seeds 3 No. of Other Members 24
Family Centroid CFAMM00224531 Functional Category Investigative Drug with Natural Product
Superfamily Zucapsacin Superfamily
Class Class 725

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Zucapsacin family 7 177
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Tubulin beta chain Inhibitor Colchinol Family 3 109
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Amine oxidase [flavin-containing] A Inhibitor 2-(4-methoxyphen... 2 7
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
NP (1s,5r,z)-2-(1-((4-methoxybenzyl)amino)ethylidene)-6,6-dime... 4 0
Putative NP ZINC04287792 Family 2 0
Putative NP ZINC00050501 Family 6 4
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224539 CHEMBL162375 Bioactive 5,6-Methylenedioxy-2-aminoindan
CFAMM00224531 DNC003324 Investigative Drug 3,4-Methylenedioxymethamphetamine
CFAMM00224533 DNC010642 Investigative Drug METHYLENEDIOXYAMPHETAMINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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