Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
CFAM Family ID CFFID998 Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2B Ligand 3,4-methylenedioxymethamphetamine Family No. of Seeds 3
No. of Other Members 24
Family Centroid CFAMM00224531 Functional Category Investigative Drug with Natural Product
Superfamily Zucapsacin Superfamily Class Class 725
Cousin Family Names Seeds Members D(2) dopamine receptor ligand catecholamine Dopamine family 9 170 Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209 Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375 Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433 Serotonin re-uptake Inhibitor Fluoxetine Family 18 682 Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29 Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74 Beta adrenergic receptor Ligand Dipivefrin Family 3 55 Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206 Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425 Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56 Alpha adrenergic receptor Ligand Bevantolol Family 4 48 Zucapsacin family 7 177 Endothelin-1 receptor Ligand Atrasentan Family 127 336 Melatonin receptor type 1A Ligand Agomelatine Family 12 164 Substance-P receptor Ligand DA-5018 Family 14 73 D(3) dopamine receptor Ligand U-99194A Family 7 33 Multidrug resistance protein Inhibitor Curcumin I Family 19 278 M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56 Tumor necrosis factor Inhibitor Y-39041 Family 9 51 5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25 Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11 Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36 Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36 5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14 Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3 5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10 Tubulin beta chain Inhibitor Colchinol Family 3 109 5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1 D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10 5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3 Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9 Amine oxidase [flavin-containing] A Inhibitor 2-(4-methoxyphen... 2 7 Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19 Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0 Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4 Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8 Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8 Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26 Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2 Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0 Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1 Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5 Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10 Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2 Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0 Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0 Benzazepines Metabolite N-Methylporphyroxine Family 1 2 NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2 NP (1s,5r,z)-2-(1-((4-methoxybenzyl)amino)ethylidene)-6,6-dime... 4 0 Putative NP ZINC04287792 Family 2 0 Putative NP ZINC00050501 Family 6 4 Putative NP ZINC08453899 Family 3 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00224521 CHEMBL177388 Bioactive
Oprea1_699373 CFAMM00224535 CHEMBL2442143 Bioactive
(2R,4R)-2,4-bis[2-(1,3-benzodioxol-5-yl)ethyl]azetidine;hydrochloride CFAMM00224536 CHEMBL2442146 Bioactive
(2R,4S)-2,4-bis[2-(1,3-benzodioxol-5-yl)ethyl]azetidine;hydrochloride CFAMM00224527 ZINC02110809 Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[(4R)-2,2-dimethyl-4-(3-methylbutyl)oxan-4-yl]ethyl]azanium CFAMM00224526 ZINC00206542 Natural Product
1,3-benzodioxol-5-ylmethyl-[(4R)-2,2-dimethyloxan-4-yl]azanium CFAMM00224541 ZINC32123839 Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[[(4R)-2,2-dimethyloxan-4-yl]azaniumyl]ethyl]azanium CFAMM00224519 ZINC02144787 Natural Product
3-[acetyl(1,3-benzodioxol-5-ylmethyl)amino]propyl-dimethylazanium CFAMM00224525 ZINC02131153 Natural Product
[(3S)-3-(1,3-benzodioxol-5-yl)-6-methylheptyl]azanium CFAMM00224540 ZINC32123838 Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[[(4S)-2,2-dimethyloxan-4-yl]azaniumyl]ethyl]azanium CFAMM00224524 ZINC02131154 Natural Product
AC1LWVUE CFAMM00224517 ZINC00206539 Natural Product
AC1LWRNB CFAMM00224530 ZINC04073421 Natural Product
AC1OF2GN CFAMM00224523 ZINC04073419 Natural Product
AC1OF2GH CFAMM00224516 ZINC00170052 Natural Product
3-amino-3-(benzo[d][1,3]dioxol-5-yl)propanoic acid CFAMM00224529 ZINC04073423 Natural Product
1,3-benzodioxol-5-ylmethyl-[2-[(2S,4R)-2-ethyl-2-methyl-4-(3-methylbutyl)oxan-4-yl]ethyl]azanium CFAMM00224522 ZINC02110810 Natural Product
AC1LX5QQ CFAMM00224515 ZINC00170053 Natural Product
(3S)-3-azaniumyl-3-(1,3-benzodioxol-5-yl)propanoate CFAMM00224528 ZINC04073422 Natural Product
AC1OF2GT CFAMM00224514 56999801 Patent Compound
AGN-PC-0BLW7J CFAMM00224520 4995343 Patent Compound
1,3-BENZODIOXOLE-5-ETHANIMIDAMIDE CFAMM00224513 57252245 Patent Compound
Ethylone CFAMM00224532 738040 Patent Compound
723284-83-1 CFAMM00224518 585277 Patent Compound
Bis-benzo[1,3]dioxol-5-ylmethyl-amine CFAMM00224538 54113749 Patent Compound
AGN-PC-0A325H
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
