CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP1380
Family Name NP 3,3,5,5-tetramethyl-6-(phenylethynyl)dihydro-2h-pyran-2,4(3h)-dione Family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00559692 Functional Category Natural Product
Superfamily 2,5-dioxo-5-[(E)-3-phenylprop-2-enoxy]pentanoate NP ZINC02151264 Superfamily
Class Class 152

Cousin Family NamesSeedsMembers
Collagenase 3 and Macrophage metalloelastase Inhibitor 5-(4'-c... 4 43
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 15
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 9
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 9
Sodium-dependent dopamine transporter inhibitor AGN-PC-074TA8 ... 2 5
Benzyloxycarbonyls Metabolite Benzyl acetate Family 5 53
Benzyloxycarbonyls Metabolite Benzyl acetoacetate Family 1 6
Putative NP ZINC55501736 Family 12 4
Putative NP ZINC06763537 Family 6 4


External ID

Functional Category

Molecule Name

CFAMM00559696 ZINC00194801 Natural Product (3R)-4,4-dimethyl-3-[(E)-2-phenylethenyl]-2-oxaspiro[5.5]undecane-1,5-dione
CFAMM00559695 ZINC00310380 Natural Product 3,3,5,5-tetramethyl-6-(phenylethynyl)dihydro-2H-pyran-2,4(3H)-dione
CFAMM00559694 ZINC00194805 Natural Product (E)-4,4-dimethyl-3-styryl-2-oxaspiro[5.5]undecane-1,5-dione
CFAMM00559692 ZINC00489022 Natural Product (6R)-3,3,5,5-tetramethyl-6-[(E)-2-phenylethenyl]oxane-2,4-dione
CFAMM00559691 ZINC00489024 Natural Product (E)-3,3,5,5-tetramethyl-6-styryldihydro-2H-pyran-2,4(3H)-dione
CFAMM00559697 ZINC00310377 Natural Product (6R)-3,3,5,5-tetramethyl-6-(2-phenylethynyl)oxane-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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