CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP1405
Family Name NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydroisoquinolin-2(1h)-yl)(2-methoxyphenyl)methanone Family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00559898 Functional Category Natural Product
Superfamily Prelamin-A/C and Cellular tumor antigen p53 Binder Superfamily 4
Class Class 92

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
Histamine H3 receptor Ligand A-349821 Family 49 228
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
D(2) dopamine receptor Ligand Epidepride Family 31 66
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Cytochrome P450 3A4 inhibitor N-[(2S,3S)-2-(1,3-benzodioxol-5-... 4 5
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-00... 5 14
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 1 5
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 1
Putative NP ZINC31164438 Family 18 0
Putative NP ZINC20113153 Family 20 0
NP (e)-4-methoxy-6,6-dimethyl-5-(2-oxo-4-(2,6,6-trimethylcyclo... 131 0
(1R,5S)-3-(2-(3,4,5-trimethoxyphenyl)acetyl)-3,4,5,6-tetrahydr... 2 0
Putative NP ZINC08791780 Family 3 0
Putative NP ZINC00519603 Family 8 1
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00559898 ZINC09058667 Natural Product ((1R,4aS,8aS)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydroisoquinolin-2(1H)-yl)(2-methoxyphenyl)methanone
CFAMM00559903 ZINC12662188 Natural Product (2,4-dimethoxyphenyl)((1R,4aS,8aS)-1-(2,5-dimethoxyphenyl)-4a-hydroxyoctahydroisoquinolin-2(1H)-yl)methanone
CFAMM00559899 ZINC04073351 Natural Product ((4aS,8aS)-4a-hydroxyoctahydroisoquinolin-2(1H)-yl)(3,4,5-trimethoxyphenyl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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