CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP1637
Family Name NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)methyl)-3-phenylbut-2-enamide Family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00561609 Functional Category Natural Product
Superfamily Substance-P receptor Ligand Ezlopitant Superfamily
Class Class 120

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Zucapsacin family 7 177
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Ivabradine family 1 11
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Transient receptor potential cation channel subfamily V member... 3 18
Cholinesterase and Acetylcholinesterase inhibitor AGN-PC-009M2... 1 6
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 4 3
Beta-lactamase inhibitor CHEMBL1316873 family 1 1
Metabotropic glutamate receptor 2 ligand 4-(3,4-dimethoxypheny... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand N-(2-... 3 0
Endothelin-converting enzyme 1 inhibitor [[(2S)-5-(2,4-difluor... 1 0
D(2) dopamine receptor ligand AGN-PC-00PT7Q family 2 1
Putative NP ZINC14589285 Family 2 1
Putative NP ZINC04041531 Family 40 0
3-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)amino... 3 0
NP N-(3,4-dimethoxyphenethyl)-2-(2-(hydroxymethyl)-5-methoxy-4... 1 0
Putative NP ZINC19322380 Family 2 2
Putative NP ZINC13119705 Family 3 0
Putative NP ZINC02099241 Family 12 0
3-benzazepin-2-one NP 7,8-dimethoxy-1h-benzo[d]azepin-2(3h)-on... 2 0
NP (e)-3-(3,4-dimethoxyphenyl)-1-((4as,8as)-4a-hydroxyoctahydr... 2 0
Putative NP ZINC08453899 Family 3 0
NP (z)-methyl 4-(4-hydroxy-3-methoxybenzylidene)-1-(3-methoxyp... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00561609 ZINC04028143 Natural Product AC1OECM8
CFAMM00561608 ZINC04028144 Natural Product (3,4-dimethoxyphenyl)methyl-[2-[(2S,4R)-2-ethyl-4-(2-methoxyphenyl)-2-methyloxan-4-yl]ethyl]azanium
CFAMM00561607 ZINC04025594 Natural Product (Z)-N-((4-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)-3-phenylbut-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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