CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP2365
Family Name ylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione NP (3s,3a'r,8a's,8b's)-2'-(2,3-dimethylphenyl)-6',7',8',8a'-tetrahydro-1'h-spiro[indoline-3,4'-pyrrolo[3,4-a]pyrrolizine]-1',2,3'(2'h,3a'h,8b'h)-trione Family
No. of Seeds 20 No. of Other Members 0
Family Centroid CFAMM00565980 Functional Category Natural Product
Superfamily Nuclear receptor ROR-gamma and Neuropeptide S receptor ligand CHEMBL1301495 Superfamily
Class Class 6045

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Motilin receptor Ligand GSK962040 Family 30 457
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00565979 ZINC20611455 Natural Product (3a'S,6a'R)-3'-benzyl-5'-cycloheptyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565972 ZINC35779869 Natural Product (3S,3a'R,8a'S,8b'S)-2'-(2,3-dimethylphenyl)-6',7',8',8a'-tetrahydro-1'H-spiro[indoline-3,4'-pyrrolo[3,4-a]pyrrolizine]-1',2,3'(2'H,3a'H,8b'H)-trione
CFAMM00565965 ZINC20611411 Natural Product (3a'S,6a'R)-3'-benzyl-5'-cyclopentyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565978 ZINC15959339 Natural Product (3a'S,6a'R)-3'-benzyl-5'-phenethyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565971 ZINC15959341 Natural Product (1R,3R,3aR,6aS)-1-benzyl-5-(2-phenylethyl)spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00565964 ZINC20611413 Natural Product AC1OF698
CFAMM00565977 ZINC15276212 Natural Product (1'S,3'S,3a'S,6a'R)-3'-methyl-5'-(naphthalen-1-yl)-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565970 ZINC20611459 Natural Product (1R,3R,3aR,6aS)-1-benzyl-5-cycloheptylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00565963 ZINC15958531 Natural Product (1'R,3'S,3a'S,6a'R)-3',5'-dibenzyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565976 ZINC49543507 Natural Product (2'R,3R,8'S)-2-oxospiro[1H-indole-3,3'-2,4,5,6,7,8-hexahydro-1H-pyrrolizin-4-ium]-2'-carboxamide
CFAMM00565969 ZINC15959342 Natural Product (1R,3S,3aR,6aS)-1-benzyl-5-(2-phenylethyl)spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00565975 ZINC20611461 Natural Product (1R,3S,3aR,6aS)-1-benzyl-5-cycloheptylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00565962 ZINC20611415 Natural Product AC1OF68Q
CFAMM00565968 ZINC15959340 Natural Product (1S,3S,3aR,6aS)-1-benzyl-5-(2-phenylethyl)spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00565961 ZINC20611417 Natural Product AC1OF692
CFAMM00565974 ZINC15958426 Natural Product (1'R,3'S,3a'S,6a'R)-3'-benzyl-5'-phenyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565967 ZINC37238672 Natural Product (3S,3a'R,8a'S,8b'S)-2'-(naphthalen-1-yl)-6',7',8',8a'-tetrahydro-1'H-spiro[indoline-3,4'-pyrrolo[3,4-a]pyrrolizine]-1',2,3'(2'H,3a'H,8b'H)-trione
CFAMM00565980 ZINC15958489 Natural Product (1'R,3'R,3a'S,6a'R)-5'-benzyl-3'-phenyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565973 ZINC15958223 Natural Product (1'R,3'S,3a'S,6a'R)-5'-(3,4-dimethylphenyl)-3'-isopropyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00565966 ZINC20611457 Natural Product (1S,3S,3aR,6aS)-1-benzyl-5-cycloheptylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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