CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP2907
Family Name 4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]benzodiazepin-3-one NP 10-(4-hydroxyphenyl)-2,3,9,10-tetrahydrobenzo[b]pyrrolo[3,4-e][1,4]diazepin-1(4h)-one Family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00568486 Functional Category Natural Product
Superfamily Niemann-Pick C1-like protein 1 Inhibitor Ezetimibe Superfamily
Class Class 418

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00568484 ZINC00226999 Natural Product (4R)-4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]benzodiazepin-3-one
CFAMM00568483 ZINC00226997 Natural Product 10-(4-methoxyphenyl)-2,3,9,10-tetrahydrobenzo[b]pyrrolo[3,4-e][1,4]diazepin-1(4H)-one
CFAMM00568486 ZINC00179022 Natural Product AC1LESJF
CFAMM00568485 ZINC00179023 Natural Product 10-(4-hydroxyphenyl)-2,3,9,10-tetrahydrobenzo[b]pyrrolo[3,4-e][1,4]diazepin-1(4H)-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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