CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP604
Family Name spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione NP ZINC35363868 Family
No. of Seeds 32 No. of Other Members 0
Family Centroid CFAMM00552178 Functional Category Natural Product
Superfamily Prothrombin and Proteasome subunit beta type-5 Binder Superfamily
Class Class 1297

Cousin Family NamesSeedsMembers
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Endothelin B receptor and Endothelin-1 receptor ligand SureCN8... 6 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00552192 ZINC15959275 Natural Product 4-((3a'S,6a'R)-3'-(3,4-dihydroxybenzyl)-2,4',6'-trioxo-3a',4',6',6a'-tetrahydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrol]-5'(3'H)-yl)phenyl acetate
CFAMM00552218 ZINC15967815 Natural Product (1R,3R,3aR,6aS)-5-benzyl-1-[(3,4-dihydroxyphenyl)methyl]-5'-ethylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552182 ZINC15958676 Natural Product (1R,3S,3aR,6aS)-5-benzyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552204 ZINC15959873 Natural Product (1S,3S,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-5-(2-phenylethyl)spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552226 ZINC15959448 Natural Product (1R,3R,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552191 ZINC15959274 Natural Product [4-[(1R,3R,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-2',4,6-trioxospiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-5-yl]phenyl] acetate
CFAMM00552217 ZINC35363867 Natural Product [4-[(1S,3S,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-2',4,6-trioxospiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-5-yl]phenyl] acetate
CFAMM00552180 ZINC15958674 Natural Product (1R,3R,3aR,6aS)-5-benzyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552202 ZINC15959871 Natural Product (3a'S,6a'R)-3'-(3,4-dihydroxybenzyl)-5'-phenethyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00552225 ZINC15959449 Natural Product (3a'S,6a'R)-3'-(3,4-dihydroxybenzyl)-5'-(4-methoxybenzyl)-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00552216 ZINC16032984 Natural Product (1R,3R,3aR,6aS)-5-cyclopentyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552190 ZINC20611894 Natural Product (1R,3S,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552179 ZINC15958675 Natural Product (1S,3S,3aR,6aS)-5-benzyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552201 ZINC15967811 Natural Product (3a'S,6a'R)-5'-benzyl-3'-(3,4-dihydroxybenzyl)-5-ethyl-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00552224 ZINC15959781 Natural Product (1R,3S,3aR,6aS)-5-cycloheptyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552189 ZINC20611895 Natural Product (1S,3S,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552215 ZINC16032985 Natural Product (1S,3S,3aR,6aS)-5-cyclopentyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552178 ZINC15958673 Natural Product (3a'S,6a'R)-5'-benzyl-3'-(3,4-dihydroxybenzyl)-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00552195 ZINC16032777 Natural Product AC1LWUOW
CFAMM00552223 ZINC15959780 Natural Product (1S,3S,3aR,6aS)-5-cycloheptyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552188 ZINC16032778 Natural Product AC1LWUOK
CFAMM00552214 ZINC15959872 Natural Product (1R,3R,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-5-(2-phenylethyl)spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552221 ZINC15967810 Natural Product (1S,3S,3aR,6aS)-5-benzyl-1-[(3,4-dihydroxyphenyl)methyl]-5'-ethylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552176 ZINC16032986 Natural Product (1R,3S,3aR,6aS)-5-cyclopentyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552194 ZINC16032776 Natural Product AC1LWUOE
CFAMM00552184 ZINC15959778 Natural Product (3a'S,6a'R)-5'-cycloheptyl-3'-(3,4-dihydroxybenzyl)-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00552212 ZINC16032983 Natural Product (3a'S,6a'R)-5'-cyclopentyl-3'-(3,4-dihydroxybenzyl)-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00552193 ZINC16032775 Natural Product (3a'S,6a'R)-5'-cyclohexyl-3'-(3,4-dihydroxybenzyl)-3',3a'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(5'H,6a'H)-trione
CFAMM00552219 ZINC15967813 Natural Product (1R,3S,3aR,6aS)-5-benzyl-1-[(3,4-dihydroxyphenyl)methyl]-5'-ethylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552183 ZINC15959779 Natural Product (1R,3R,3aR,6aS)-5-cycloheptyl-1-[(3,4-dihydroxyphenyl)methyl]spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552205 ZINC15959874 Natural Product (1R,3S,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-5-(2-phenylethyl)spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione
CFAMM00552227 ZINC35363868 Natural Product [4-[(1R,3S,3aR,6aS)-1-[(3,4-dihydroxyphenyl)methyl]-2',4,6-trioxospiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-5-yl]phenyl] acetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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