CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP663
Family Name 12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione NP (s)-2-(3-hydroxypropyl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6h,7h)-dione Family
No. of Seeds 11 No. of Other Members 0
Family Centroid CFAMM00553036 Functional Category Natural Product
Superfamily Prelamin-A/C and Cholinesterase Binder Superfamily 2
Class Class 173

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]i... 16 0
(S)-2-amino-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4... 1 0
2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(1... 3 0
6-(3-nitrophenyl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyri... 16 0
8'-fluoro-6'-methyl-2,3,4,5',6',9-hexahydrodispiro[beta-carbol... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00553039 ZINC04084128 Natural Product (12bS)-7-(4-ethylphenyl)-2-(2-hydroxyethyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553032 ZINC12873709 Natural Product (12bS)-7-(4-ethylphenyl)-2-(3-isopropoxypropyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553038 ZINC02140249 Natural Product (S)-2-(3-hydroxypropyl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione
CFAMM00553031 ZINC12873449 Natural Product (12bS)-2-(3-butoxypropyl)-7-(4-ethylphenyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553037 ZINC08789209 Natural Product (12bS)-7-(4-ethylphenyl)-2-(3-hydroxypropyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553030 ZINC12873702 Natural Product 7-(4-ethylphenyl)-2-(3-isopropoxypropyl)-12b-methyl-2,3,6,7,12,12b-hexahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4-dione
CFAMM00553036 ZINC08789208 Natural Product (12bS)-7-(4-ethylphenyl)-2-(3-hydroxypropyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553035 ZINC12873441 Natural Product (12bS)-2-(3-butoxypropyl)-7-(4-ethylphenyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553034 ZINC04084127 Natural Product (12bS)-7-(4-ethylphenyl)-2-(2-hydroxyethyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553040 ZINC04029719 Natural Product (S)-2-(5-hydroxypentyl)-12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(12H,12bH)-dione
CFAMM00553033 ZINC02087569 Natural Product (S)-2-(3-hydroxypropyl)-6,6-dimethyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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