CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFNP920
Family Name NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan-8-yl 3-bromobenzoate Family
No. of Seeds 13 No. of Other Members 3
Family Centroid CFAMM00555672 Functional Category Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5-diphenyl-furan-3-yl)-phenyl-methanone Superfamily
Class Class 1672

Cousin Family NamesSeedsMembers
Potassium voltage-gated channel subfamily H member 2 Ligand Am... 2 16
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Ipriflavone family 62 2480
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5... 1 9
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Kappa-type opioid receptor Ligand Salvinorin B Butoxymethyl Et... 38 215
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Prostaglandin D2 receptor 2 Ligand 2-(2-benzoyl-4-bromophenoxy... 4 35
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Reverse transcriptase/RNaseH inhibitor AC1O5CPP family 1 5
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Corticosteroid 11-beta-dehydrogenase isozyme 2 and Corticoster... 1 2
Furans Metabolite Perilla ketone Family 2 5
Prenol Lipids Metabolite Furanogermenone Family 2 2
Fatty Acids and Conjugates Metabolite 3,4-Dimethyl-5-pentyl-2-... 2 2
Putative NP ZINC31165975 Family 4 0
Putative NP ZINC31158464 Family 3 5
1,3-dimethylcyclohepta[c]furan-8-one NP 8-hydroxy-6-(4-methoxy... 10 0
5,6-dihydro-4H-furo[2',3':3,4]cyclohepta[1,2-b][1]benzofuran N... 3 0
(6-bromo-5,8-dioxonaphthalen-1-yl) acetate NP 6-bromo-5,8-diox... 1 1
NP 3-(6-bromo-4h-benzo[d][1,3]dioxin-8-yl)-4h-chromen-4-one Fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00555664 ZINC02104103 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 4-methylbenzoate
CFAMM00555677 ZINC01774193 Natural Product 6-(4-methoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 2-bromobenzoate
CFAMM00555670 ZINC02103730 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 2-methylbenzoate
CFAMM00555663 ZINC02103598 Natural Product 6-(4-methoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl cinnamate
CFAMM00555676 ZINC01094565 Natural Product 6-(4-methoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 4-fluorobenzoate
CFAMM00555675 ZINC02100681 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl cinnamate
CFAMM00555662 ZINC02103595 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 2-bromobenzoate
CFAMM00555668 ZINC02102271 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 4-fluorobenzoate
CFAMM00555667 ZINC02155387 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 3-bromobenzoate
CFAMM00555673 ZINC02107793 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 2-fluorobenzoate
CFAMM00555672 ZINC02097120 Natural Product 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl benzoate
CFAMM00555665 ZINC02102849 Natural Product 6-(4-methoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 2-methylbenzoate
CFAMM00555671 ZINC02105317 Natural Product 6-(4-methoxyphenyl)-1,3-dimethyl-4-oxo-4H-cyclohepta[c]furan-8-yl 3-bromobenzoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27276 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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