CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Superfamily Information

CFAM Superfamily ID CFSBM192
Superfamily Name Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Functional Category Bioactive with Natural Product
No. of Members 24
Class Class 1070

Member Families of This Superfamily

Family NameSeedsMembers
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Cyclin-dependent kinase 2 inhibitor AGN-PC-075HD8 family 1 0
Glucagon receptor ligand 3-[[4-[1-[4-[4-(trifluoromethyl)imida... 1 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Putative Fused Heterocyclic Compounds As Protein Tyrosine Kina... 1 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Renin inhibitor [2-(5-fluoro-2-methylphenoxy)-5-hydroxy-1-phen... 2 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Transient receptor potential cation channel subfamily V member... 2 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04S3QV family 1 2
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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