CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Superfamily Information

CFAM Superfamily ID CFSBM492
Superfamily Name Dihydrofolate reductase and Dual specificity protein kinase TTK Binder Superfamily
Functional Category Bioactive with Natural Product
No. of Members 16
Class Class 831

Member Families of This Superfamily

Family NameSeedsMembers
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-00QO9F family 2 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Lysine--tRNA ligase and Tyrosine-protein kinase Lyn inhibitor ... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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