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PROFEAT - Protein Feature Server (2016)                                                                                        Return to HOME

PROFEAT is a web server for computing commonly used proteins features from amino acid sequence, and interaction network properties from network structure.

🔑 Reference Manual and User Guide
🔑 Network Descriptor Tutorial NEW!
🔑 Structure Descriptor Tutorial NEW!

Protein-Ligand Interaction Pair Descriptors

upload your protein-ligand pair,             or upload sample protein-ligand pair

Please upload the

protein sequence, ligand SDF and protein-ligand pair files here:

Upload Proteins


File format of Proteins can be found HERE

Upload Ligand


File format of Ligand can be found HERE

Upload PLI Pairs


File format of PLI Pairs can be found HERE

How to cite our database

P. Zhang, L. Tao, X. Zeng, C. Qin, S.Y. Chen, F. Zhu, Z.R. Li, Y.Y. Jiang, W.P. Chen, Y.Z. Chen. A protein network descriptor server and its use in studying protein, disease, metabolic and drug targeted networks. Brief Bioinform. pii: bbw071 (2016).

P. Zhang, L. Tao, X. Zeng, C. Qin, S.Y. Chen, F. Zhu, S.Y. Yang, Z.R. Li, W.P. Chen, Y.Z. Chen. PROFEAT Update: A Protein Features Web Server with Added Facility to Compute Network Descriptors for Studying Omics-Derived Networks. J Mol Biol. pii:S0022-2836(16)30428-4. (2016).

H.B. Rao, F. Zhu, G.B. Yang, Z.R. Li, and Y.Z. Chen. Update of PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence. Nucleic Acids Res. Jul 1, 2011; 39(Web Server issue):W385-90.

Z.R. Li, H.H. Lin, L.Y. Han, L. Jiang, X. Chen, and Y.Z. Chen. PROFEAT: A Web Server for Computing Structural and Physicochemical Features of Proteins and Peptides from Amino Acid Sequence. Nucleic Acids Res. Jul 1, 2006; 34(Web Server issue):W32-7.

List of Publications That Used the Features in PROFEAT

The earlier version of PROFEAT can be found HERE.

Last updated: 30 May 2016

visits since November 6, 2005


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If you find any error in data or bug in web service, please kindly report it to Dr. Tao Lin or Mr. Zhang Peng.



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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